2023
Core Constituents of Caragana sinica Root for Rheumatoid Arthritis Treatment and the Potential Mechanism
Qu B, Wang S, Zhu H, Yin T, Zhou R, Hu W, Lu C. Core Constituents of Caragana sinica Root for Rheumatoid Arthritis Treatment and the Potential Mechanism. ACS Omega 2023, 8: 2586-2595. PMID: 36687056, PMCID: PMC9851025, DOI: 10.1021/acsomega.2c07094.Peer-Reviewed Original ResearchRheumatoid arthritis treatmentAnti-inflammatory effectsRA treatmentEthyl acetate extractArthritis treatmentHerbal constituentsPotential mechanismsNuclear factor kappa B (NF-κB) signal pathwayGood anti-inflammatory effectAnti-arthritis effectsUltra-performance liquid chromatographyNF-κB p65Herb productsB signal pathwayNF-κB pathwayArthritis ratsBioinformatics analysisBetter efficacyTherapeutic efficacyPharmacological roleOral bioavailabilityDrug-like propertiesFolk medicineSignal pathwayTreatment
2017
Interleukin-1β and tumor necrosis factor-α augment acidosis-induced rat articular chondrocyte apoptosis via nuclear factor-kappaB-dependent upregulation of ASIC1a channel
Zhou R, Dai B, Xie Y, Wu X, Wang Z, Li Y, Wang Z, Zu S, Ge J, Chen F. Interleukin-1β and tumor necrosis factor-α augment acidosis-induced rat articular chondrocyte apoptosis via nuclear factor-kappaB-dependent upregulation of ASIC1a channel. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2017, 1864: 162-177. PMID: 28986307, DOI: 10.1016/j.bbadis.2017.10.004.Peer-Reviewed Original ResearchConceptsAcid-sensing ion channel 1aIL-1βRheumatoid arthritisInterleukin-1βNF-κB inhibitor ammonium pyrrolidinedithiocarbamateNF-κB DNA-binding activityPrimary articular chondrocytesProinflammatory cytokine interleukin-1βAcidosis-induced cytotoxicityCytokines interleukin-1βTumor necrosis factorImportant pathological characteristicNF-κB pathwayArticular chondrocyte apoptosisCaspase-3/9 expressionIon channel 1aNuclear factor-kappaBPleiotropic biological effectsArticular chondrocytesAgent BAPTA-AMASIC1a expressionChondrocyte cytotoxicityΚB expressionAdjuvant arthritisPathological characteristics