2020
Acid‐sensing ion channel 1a mediates acid‐induced pyroptosis through calpain‐2/calcineurin pathway in rat articular chondrocytes
Zu S, Feng Y, Zhu C, Wu X, Zhou R, Li G, Dai B, Wang Z, Xie Y, Li Y, Ge J, Chen F. Acid‐sensing ion channel 1a mediates acid‐induced pyroptosis through calpain‐2/calcineurin pathway in rat articular chondrocytes. Cell Biology International 2020, 44: 2140-2152. PMID: 32678496, DOI: 10.1002/cbin.11422.Peer-Reviewed Original ResearchConceptsAcid-sensing ion channel 1aAcid-sensing ion channelsRat articular chondrocytesIon channel 1aChondrocyte pyroptosisTime-dependent mannerCalpain-2Activation of ASICsChannel 1aExtracellular acidosisInhibition of ASIC1aProtein expressionInterleukin-1β levelsArticular chondrocytesSystemic autoimmune diseasePrimary rat articular chondrocytesApoptosis-associated speck-like proteinNLRP3 inflammasome proteinsCalcineurin pathwaySpeck-like proteinCation channel familyRheumatoid arthritisAutoimmune diseasesDegenerative articular cartilageInflammasome proteins
2017
Effects of autophagy on acid-sensing ion channel 1a-mediated apoptosis in rat articular chondrocytes
Xie Y, Li Y, Zhou R, Dai B, Qian Y, Wu X, Ge J, Hu W, Chen F. Effects of autophagy on acid-sensing ion channel 1a-mediated apoptosis in rat articular chondrocytes. Molecular And Cellular Biochemistry 2017, 443: 181-191. PMID: 29273849, DOI: 10.1007/s11010-017-3223-6.Peer-Reviewed Original ResearchConceptsRat articular chondrocytesRheumatoid arthritisEffect of autophagyPathogenesis of RAArticular chondrocytesProgression of RAInhibition of ASIC1aAcid-sensing ion channel 1aMultiple pathogenic factorsDegenerative joint diseaseArticular chondrocyte apoptosisRat knee jointsIon channel 1aShort hairpin RNAPrecise etiologyJoint diseasePathogenic factorsKnee jointPsalmotoxin-1Chondrocyte apoptosisPrimary articular chondrocytesChannel 1aASIC1aAutophagy fluxBeclin-1ASIC1a Promotes Acid-Induced Autophagy in Rat Articular Chondrocytes through the AMPK/FoxO3a Pathway
Dai B, Zhu F, Chen Y, Zhou R, Wang Z, Xie Y, Wu X, Zu S, Li G, Ge J, Chen F. ASIC1a Promotes Acid-Induced Autophagy in Rat Articular Chondrocytes through the AMPK/FoxO3a Pathway. International Journal Of Molecular Sciences 2017, 18: 2125. PMID: 29019932, PMCID: PMC5666807, DOI: 10.3390/ijms18102125.Peer-Reviewed Original Research