IUPHAR ECR review: The cGAS-STING pathway: Novel functions beyond innate immune and emerging therapeutic opportunities
He X, Wedn A, Wang J, Gu Y, Liu H, Zhang J, Lin Z, Zhou R, Pang X, Cui Y. IUPHAR ECR review: The cGAS-STING pathway: Novel functions beyond innate immune and emerging therapeutic opportunities. Pharmacological Research 2024, 201: 107063. PMID: 38216006, DOI: 10.1016/j.phrs.2024.107063.Peer-Reviewed Original ResearchStimulator of interferon genesAdaptor protein complex 1Function of STINGRegulation of cellular metabolismRegulatory functionsRegulation of stimulator of interferon genesInnate immune signaling pathwaysImmune signaling pathwaysInnate immune regulationInnate immune sensorsCellular physiologyCGAS-STING pathwayDNA repairNegative regulatorComplex regulationCellular metabolismCytosolic DNAStimulator of interferon genes agonistsCell deathAP-1Stimulators of interferon genes signallingSignaling pathwayMolecular mechanismsImmune regulatory drugImmune sensors