2023
Effects of short-term endurance and strength exercise in the molecular regulation of skeletal muscle in hyperinsulinemic and hyperglycemic Slc2a4+/− mice
Muñoz V, Botezelli J, Gaspar R, da Rocha A, Vieira R, Crisol B, Braga R, Severino M, Nakandakari S, Antunes G, Brunetto S, Ramos C, Velloso L, Simabuco F, de Moura L, da Silva A, Ropelle E, Cintra D, Pauli J. Effects of short-term endurance and strength exercise in the molecular regulation of skeletal muscle in hyperinsulinemic and hyperglycemic Slc2a4+/− mice. Cellular And Molecular Life Sciences 2023, 80: 122. PMID: 37052684, PMCID: PMC11072257, DOI: 10.1007/s00018-023-04771-2.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDiabetes Mellitus, Type 2GlucoseGlucose Transporter Type 4HyperglycemiaInsulin ResistanceMiceMuscle, SkeletalConceptsWhole-body glucose homeostasisSkeletal muscle glucose uptakeMuscle glucose uptakeMitochondrial adaptationsMitochondrial activityPost-translational mechanismsSkeletal muscleGlucose uptakeC2C12 cell lineInsulin resistanceStrength exercisesGlucose homeostasisMouse modelPhysical exerciseProtein response markersShort-term physical activityMolecular regulationTranscriptomic modulationRNA sequencingImpact of hyperglycemiaC2C12 cellsStrength exercise trainingType 2 diabetesStrength training protocolsMitochondrial function
2017
Physical exercise reduces pyruvate carboxylase (PCB) and contributes to hyperglycemia reduction in obese mice
Muñoz V, Gaspar R, Crisol B, Formigari G, Sant’Ana M, Botezelli J, Gaspar R, da Silva A, Cintra D, de Moura L, Ropelle E, Pauli J. Physical exercise reduces pyruvate carboxylase (PCB) and contributes to hyperglycemia reduction in obese mice. The Journal Of Physiological Sciences 2017, 68: 493-501. PMID: 28710665, PMCID: PMC10717866, DOI: 10.1007/s12576-017-0559-3.Peer-Reviewed Original ResearchConceptsDiet-induced obesityObesity-inducing dietInsulin tolerance testObese micePhysical exerciseDIO miceExercise trainingControl miceHepatic tissueStandard rodent chowDevelopment of hyperglycemiaExercise training protocolType 2 diabetesTreadmill running protocolPhysical exercise sessionGlucose homeostasis controlEXE miceHyperglycemia reductionObese conditionsRodent chowTolerance testSerum glucoseSwiss miceExercise sessionsEpididymal fat