Acute physical exercise increases leptin‐induced hypothalamic extracellular signal‐regulated kinase1/2 phosphorylation and thermogenesis of obese mice
Gaspar R, Muñoz V, Kuga G, Nakandakari S, Minuzzi L, Botezelli J, da Silva A, Cintra D, de Moura L, Ropelle E, Pauli J. Acute physical exercise increases leptin‐induced hypothalamic extracellular signal‐regulated kinase1/2 phosphorylation and thermogenesis of obese mice. Journal Of Cellular Biochemistry 2018, 120: 697-704. PMID: 30206970, DOI: 10.1002/jcb.27426.Peer-Reviewed Original ResearchConceptsAcute physical exerciseBrown adipose tissueObese micePhysical exerciseEnergy expenditureERK1/2 phosphorylationTreatment of obesityExtracellular signal-regulated kinase1/2 (ERK1/2) phosphorylationProtein 1 (UCP1) contentExtracellular signal-regulated kinase 1/2Signal-regulated kinase 1/2Sympathetic signalsSpontaneous activityAdipose tissueP-ERK1/2Main interventionThermoregulatory effectsMiceKey mediatorThermogenesisOxygen uptakeMolecular changesKinase 1/2ObeseObesityPhysical training reverses changes in hepatic mitochondrial diameter of Alloxan-induced diabetic rats
Kuga G, Gaspar R, Muñoz V, Nakandakari S, Breda L, Sandoval B, Caetano F, de Almeida Leme J, Pauli J, Gomes R. Physical training reverses changes in hepatic mitochondrial diameter of Alloxan-induced diabetic rats. Einstein (São Paulo) 2018, 16: eao4353. PMID: 30088548, PMCID: PMC6110382, DOI: 10.1590/s1679-45082018ao4353.Peer-Reviewed Original ResearchConceptsDiabetic ratsBody weightDiabetic groupSedentary diabeticDiabetic animalsPhysical trainingSedentary diabetic animalsPhysical training protocolMitochondrial diameterDiabetes mellitusAlloxan administrationBlood insulinExercise protocolSerum glucoseSedentary controlsWistar ratsHepatic metabolismReverses changesLiver glycogenHepatic glycogenDiabeticsRatsMeasurements of glycogenLiver samplesTraining protocol