2019
Acute physical exercise increases APPL1/PI3K signaling in the hypothalamus of lean mice
Gaspar R, Muñoz V, Kuga G, Nakandakari S, Crisol B, Lenhare L, Breda L, Botezelli J, Sant'Ana M, da Silva A, Cintra D, de Moura L, Ropelle E, Pauli J. Acute physical exercise increases APPL1/PI3K signaling in the hypothalamus of lean mice. European Journal Of Neuroscience 2019, 50: 3181-3190. PMID: 31206806, DOI: 10.1111/ejn.14490.Peer-Reviewed Original ResearchConceptsLean miceExercise sessionsPhysical exerciseAcute exercise sessionAcute physical exercisePhysical exercise sessionPI3K p110PI3K mRNAAdiponectin pathwayArcuate nucleusSwiss miceHypothalamusAdiponectinEnergy homeostasisMiceMRNA levelsPI3KFood consumptionLeucine zipper motif 1BXD miceExerciseK mRNAPresent studyPositive correlationKey proteins
2017
Physical exercise reduces pyruvate carboxylase (PCB) and contributes to hyperglycemia reduction in obese mice
Muñoz V, Gaspar R, Crisol B, Formigari G, Sant’Ana M, Botezelli J, Gaspar R, da Silva A, Cintra D, de Moura L, Ropelle E, Pauli J. Physical exercise reduces pyruvate carboxylase (PCB) and contributes to hyperglycemia reduction in obese mice. The Journal Of Physiological Sciences 2017, 68: 493-501. PMID: 28710665, PMCID: PMC10717866, DOI: 10.1007/s12576-017-0559-3.Peer-Reviewed Original ResearchConceptsDiet-induced obesityObesity-inducing dietInsulin tolerance testObese micePhysical exerciseDIO miceExercise trainingControl miceHepatic tissueStandard rodent chowDevelopment of hyperglycemiaExercise training protocolType 2 diabetesTreadmill running protocolPhysical exercise sessionGlucose homeostasis controlEXE miceHyperglycemia reductionObese conditionsRodent chowTolerance testSerum glucoseSwiss miceExercise sessionsEpididymal fat