2020
Aging is associated with increased TRB3, ER stress, and hepatic glucose production in the liver of rats
Gaspar R, Muñoz V, Nakandakari S, Vieira R, da Conceição L, de Oliveira F, Crisol B, da Silva A, Cintra D, de Moura L, Ropelle E, Zaghloul I, Mekary R, Pauli J. Aging is associated with increased TRB3, ER stress, and hepatic glucose production in the liver of rats. Experimental Gerontology 2020, 139: 111021. PMID: 32659331, DOI: 10.1016/j.exger.2020.111021.Peer-Reviewed Original ResearchConceptsER stressEukaryotic translation initiation factorProtein kinase RNA-like endoplasmic reticulum kinaseRNA-like endoplasmic reticulum kinaseTranslation initiation factorPhosphorylation of inositolStress response regulationEndoplasmic reticulum kinaseEndoplasmic reticulum stress pathwayMammalian homologDrosophila tribblesEndoplasmic reticulum stressInitiation factorsProtein contentTRB3Multiple tissuesStress pathwaysImmunoglobulin proteinEnzymes of gluconeogenesisReticulum stressHepatic glucose productionEnzyme 1Response regulationMolecular changesPyruvate challenge
2019
Tlr4 participates in the responses of markers of apoptosis, inflammation, and ER stress to different acute exercise intensities in mice hearts
de Vicente L, Pinto A, Muñoz V, Rovina R, da Rocha A, Gaspar R, da Silva L, Simabuco F, Frantz F, Pauli J, de Moura L, Cintra D, Ropelle E, da Silva A. Tlr4 participates in the responses of markers of apoptosis, inflammation, and ER stress to different acute exercise intensities in mice hearts. Life Sciences 2019, 240: 117107. PMID: 31785241, DOI: 10.1016/j.lfs.2019.117107.Peer-Reviewed Original ResearchConceptsAcute exercise intensityAcute physical exerciseLeft ventricleTLR4 deletionIL-17Serum levelsTNF-alphaPhysical exerciseExercise intensityER stressToll-like receptor 4Heart mRNA levelsSame exercise conditionTLR4 KO miceRole of TLR4Myocardium of miceExpression of inflammationResponse of markersEndoplasmic reticulum stressKO miceReceptor 4CK-MBImmune responseInflammationER stress genesShort-term high-fat diet modulates several inflammatory, ER stress, and apoptosis markers in the hippocampus of young mice
Nakandakari S, Muñoz V, Kuga G, Gaspar R, Sant'Ana M, Pavan I, da Silva L, Morelli A, Simabuco F, da Silva A, de Moura L, Ropelle E, Cintra D, Pauli J. Short-term high-fat diet modulates several inflammatory, ER stress, and apoptosis markers in the hippocampus of young mice. Brain Behavior And Immunity 2019, 79: 284-293. PMID: 30797044, DOI: 10.1016/j.bbi.2019.02.016.Peer-Reviewed Original ResearchConceptsHigh-fat dietYoung miceShort-term HFD feedingMice fed high-fat dietFed high-fat dietHippocampus of miceER stressDisease developmentShort-term consumptionAlzheimer's disease developmentPotential molecular mechanismsHOMA-IRHFD feedingAD markersMicroglial cellsAD pathogenesisRisk factorsInflammatory signalsDiet modulatesΒ-amyloidCleaved caspase3HippocampusApoptosis markersHigh expressionMiceExhaustive acute exercise-induced ER stress is attenuated in IL-6-knockout mice
Pinto A, da Rocha A, Kohama E, Gaspar R, Simabuco F, Frantz F, de Moura L, Pauli J, Cintra D, Ropelle E, de Freitas E, da Silva A. Exhaustive acute exercise-induced ER stress is attenuated in IL-6-knockout mice. Journal Of Endocrinology 2019, 240: 181-193. PMID: 30400033, DOI: 10.1530/joe-18-0404.Peer-Reviewed Original ResearchConceptsIL-6 knockout miceExtensor digitorium longusPhysical exercise protocolAcute exercise protocolER stress proteinsExercise protocolIL-6WT groupIL-6 KO groupSerum levelsKO groupExercise-induced IL-6IL-6 concentrationsWild-type miceIntense physical exerciseER stressEndoplasmic reticulum stressStress proteinsIL-10Interleukin-6Knockout micePhysical exerciseSoleusHomeostatic functionsMice