2018
Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B
Kuga G, Muñoz V, Gaspar R, Nakandakari S, da Silva A, Botezelli J, Leme J, Gomes R, de Moura L, Cintra D, Ropelle E, Pauli J. Impaired insulin signaling and spatial learning in middle-aged rats: The role of PTP1B. Experimental Gerontology 2018, 104: 66-71. PMID: 29421605, DOI: 10.1016/j.exger.2018.02.005.Peer-Reviewed Original ResearchConceptsMiddle-aged ratsBrain-derived neurotrophic factorΒ-amyloid contentAlzheimer's diseaseInsulin resistanceTau phosphorylationMorris water maze testMiddle-aged Wistar ratsInsulin tolerance testMain risk factorsAge-related changesNeurotrophic factorTolerance testRisk factorsMaze testImpaired insulinWistar ratsNew therapiesHippocampus regionBody weightCognitive declineRole of PTP1BSynaptic plasticityRatsSpatial learning
2017
Hippocampal insulin signaling and neuroprotection mediated by physical exercise in Alzheimer´s Disease
Kuga G, Botezelli J, Gaspar R, Gomes R, Pauli J, de Almeida Leme J. Hippocampal insulin signaling and neuroprotection mediated by physical exercise in Alzheimer´s Disease. Motriz Revista De Educação Física 2017, 23: e101608. DOI: 10.1590/s1980-6574201700si0008.Peer-Reviewed Original ResearchTreatment of ADAlzheimer's diseaseNeuronal survivalLow-grade inflammationAnti-inflammatory effectsNon-pharmacological alternativesAD genesisHippocampal insulinHippocampal neurodegenerationHippocampal neuroprotectionNeuroprotective mechanismsInsulin sensitivityEpidemiological studiesPhysical exerciseHippocampal integrityDiseaseInsulinNeuroprotectionExercisePreventionMolecular mechanismsSurvivalTreatmentIntense research effortsPowerful activator