PRL3 induces polyploid giant cancer cells eliminated by PRL3-zumab to reduce tumor relapse
Thura M, Ye Z, Al-Aidaroos A, Xiong Q, Ong J, Gupta A, Li J, Guo K, Ang K, Zeng Q. PRL3 induces polyploid giant cancer cells eliminated by PRL3-zumab to reduce tumor relapse. Communications Biology 2021, 4: 923. PMID: 34326464, PMCID: PMC8322210, DOI: 10.1038/s42003-021-02449-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsGiant CellsImmediate-Early ProteinsMiceNeoplasmsPolyploidyProtein Tyrosine PhosphatasesSecondary PreventionConceptsTumor relapsePhase 2 clinical trialStem cell markers SOX2Cell markers SOX2Polyploid giant cancer cellsTumor removal surgeryStem-like cellsAdjuvant immunotherapyGiant cancer cellsPrimary tumorClinical trialsTumor removalCancer cell formationAnimal modelsRelapse tumorsSolid tumorsRelapseRemoval surgeryEmbryonic stem cell markers SOX2TumorsAntibody drugsCancer cellsExtensive DNA damageMetastasisCell survival