2023
Longitudinal Comparative Analysis of Complications and Subsequent Interventions Following Stand-Alone Interspinous Spacers, Open Decompression, or Fusion for Lumbar Stenosis
Whang P, Tran O, Rosner H. Longitudinal Comparative Analysis of Complications and Subsequent Interventions Following Stand-Alone Interspinous Spacers, Open Decompression, or Fusion for Lumbar Stenosis. Advances In Therapy 2023, 40: 3512-3524. PMID: 37289411, PMCID: PMC10329952, DOI: 10.1007/s12325-023-02562-6.Peer-Reviewed Original ResearchConceptsLong-term complicationsLumbar spinal stenosisLumbar spine surgeryFirst surgical interventionLife-threatening eventsSurgical interventionISD patientsSurgery cohortOpen decompressionOpen surgerySpine surgerySubsequent interventionsComplication-related costsOpen surgery cohortSubsequent surgical interventionInterspinous spacer devicesFusion cohortLSS patientsConservative therapyBaseline characteristicsPatient agePostoperative outcomesLumbar stenosisSpinal stenosisMedicare database
2022
Not all well-differentiated cutaneous squamous cell carcinomas are equal: Tumors with disparate biologic behavior have differences in protein expression via digital spatial profiling
Vesely M, Martinez-Morilla S, Gehlhausen JR, McNiff JM, Whang PG, Rimm D, Ko CJ. Not all well-differentiated cutaneous squamous cell carcinomas are equal: Tumors with disparate biologic behavior have differences in protein expression via digital spatial profiling. Journal Of The American Academy Of Dermatology 2022, 87: 695-698. PMID: 35398219, DOI: 10.1016/j.jaad.2022.03.057.Peer-Reviewed Original ResearchEvidence-based Recommendations for Spine Surgery
Fisher CG, Vaccaro AR, Mahtabfar A, Mulpuri K, Evanview N, Dea N, Makanji H, Whang PG, Heller JE. Evidence-based Recommendations for Spine Surgery. Spine 2022, 47: 967-975. PMID: 35238857, DOI: 10.1097/brs.0000000000004350.Peer-Reviewed Original Research
2021
Evidence-based Recommendations for Spine Surgery
Vaccaro AR, Fisher CG, Prasad SK, Whang PG, Dea N, Thomas KC, Mulpuri K, Makanji HS. Evidence-based Recommendations for Spine Surgery. Spine 2021, 46: 975-982. PMID: 34160375, DOI: 10.1097/brs.0000000000004091.Peer-Reviewed Original ResearchHPyV6‐ and HPyV7‐negative parakeratosis and dyskeratosis in squamous cell carcinoma in situ
Ko CJ, Wang A, Panse G, Lee EE, Wang RC, Whang PG, Bosenberg M, Damsky W. HPyV6‐ and HPyV7‐negative parakeratosis and dyskeratosis in squamous cell carcinoma in situ. Journal Of Cutaneous Pathology 2021, 48: 998-1000. PMID: 33813761, DOI: 10.1111/cup.14022.Peer-Reviewed Original ResearchBrain Structure and Function of Chronic Low Back Pain Patients on Long-Term Opioid Analgesic Treatment: A Preliminary Study
Murray K, Lin Y, Makary MM, Whang PG, Geha P. Brain Structure and Function of Chronic Low Back Pain Patients on Long-Term Opioid Analgesic Treatment: A Preliminary Study. Molecular Pain 2021, 17: 1744806921990938. PMID: 33567986, PMCID: PMC7883154, DOI: 10.1177/1744806921990938.Peer-Reviewed Original ResearchConceptsChronic low back painOpioid analgesicsCLBP patientsPain patientsChronic low back pain patientsLow back pain patientsBrain structuresOpioid analgesic treatmentBack pain patientsClasses of medicationsChronic pain patientsLow back painLong-term riskAltered brain structureSub-cortical areasOverall significant decreaseEvidence of misuseAnalgesic treatmentChronic treatmentBack painFunctional brain imagingLimbic areasUnmedicated patientsHealthy controlsNucleus accumbens
2020
Evidence-based Recommendations for Spine Surgery.
Vaccaro AR, Fisher CG, Prasad SK, Makanji HS, Mulpuri K, Thomas KC, Dea N, Chi J, Whang PG. Evidence-based Recommendations for Spine Surgery. Spine 2020, 46: e277-e285. PMID: 33290372, DOI: 10.1097/brs.0000000000003838.Peer-Reviewed Original ResearchEvidence-Based Recommendations for Spine Surgery.
Fisher CG, Vaccaro AR, Patel AA, Whang PG, Thomas KC, Chi J, Mulpuri K, Prasad SK. Evidence-Based Recommendations for Spine Surgery. Spine 2020, 45: 851-859. PMID: 32355150, DOI: 10.1097/brs.0000000000003512.Peer-Reviewed Original ResearchConceptsSpine surgeryDecompression surgeryLumbar decompression surgerySpinal decompression surgeryPost-operative MRISagittal spinopelvic alignmentEvidence-based recommendationsLumbar disc arthroplastyLumbar surgeryPrognostic factorsTranexamic acidOsteoporotic patientsDisc arthroplastySpinopelvic alignmentSurgeryClinical practiceComparative effectivenessPatientsArthroplastyRecommendationsFusion supportMRILoss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain
Makary MM, Polosecki P, Cecchi GA, DeAraujo IE, Barron DS, Constable TR, Whang PG, Thomas DA, Mowafi H, Small DM, Geha P. Loss of nucleus accumbens low-frequency fluctuations is a signature of chronic pain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 10015-10023. PMID: 32312809, PMCID: PMC7211984, DOI: 10.1073/pnas.1918682117.Peer-Reviewed Original ResearchConceptsChronic low back pain patientsLow back pain patientsChronic painPain patientsChronic phaseChronic back pain patientsBack pain patientsRostral anterior cingulate cortexAnterior cingulate cortexAdditional independent datasetsRisk of transitionResting-state activityPersistent painBack painAccumbens volumeHealthy controlsNucleus accumbensPainSeparate cohortPatientsCingulate cortexPrevalent diseaseFunctional connectivityLoss of nucleiSubcortical signatures
2017
Evidence-Based Recommendations for Spine Surgery
Vaccaro AR, Fisher CG, Patel AA, Prasad SK, Chi J, Mulpuri K, Thomas KC, Whang PG. Evidence-Based Recommendations for Spine Surgery. Spine 2017, 42: e435-e442. PMID: 28240652, DOI: 10.1097/brs.0000000000002083.Peer-Reviewed Original ResearchPredictors of Outcome in Conservative and Minimally Invasive Surgical Management of Pain Originating From the Sacroiliac Joint
Dengler J, Duhon B, Whang P, Frank C, Glaser J, Sturesson B, Garfin S, Cher D, Rendahl A, Polly D. Predictors of Outcome in Conservative and Minimally Invasive Surgical Management of Pain Originating From the Sacroiliac Joint. Spine 2017, 42: 1664-1673. PMID: 28350586, PMCID: PMC5636200, DOI: 10.1097/brs.0000000000002169.Peer-Reviewed Original ResearchConceptsOswestry Disability IndexPredictors of outcomeSIJ fusionVisual analog scaleInvasive surgical managementSacroiliac jointSIJ painTreatment outcomesConservative managementProspective trialSurgical managementSingle-arm prospective trialInvasive SIJ fusionLonger pain durationLower patient ageInvasive surgical treatmentIndividual patient dataPatient-level analysisTriangular titanium implantsBetter treatment outcomesAnalysis of predictorsRandom-effects modelMultivariate regression analysisTrial sample sizeNonopioid users
2016
Evidence-based Recommendations for Spine Surgery
Vaccaro AR, Fisher CG, Prasad SK, Patel AA, Chi J, Mulpuri K, Thomas KC, Whang PG. Evidence-based Recommendations for Spine Surgery. Spine 2016, 41: e165-e173. PMID: 26650873, DOI: 10.1097/brs.0000000000001369.Peer-Reviewed Original Research
2015
Randomized Controlled Trial of Minimally Invasive Sacroiliac Joint Fusion Using Triangular Titanium Implants vs Nonsurgical Management for Sacroiliac Joint Dysfunction: 12-Month Outcomes
Polly DW, Cher DJ, Wine KD, Whang PG, Frank CJ, Harvey CF, Lockstadt H, Glaser JA, Limoni RP, Sembrano JN. Randomized Controlled Trial of Minimally Invasive Sacroiliac Joint Fusion Using Triangular Titanium Implants vs Nonsurgical Management for Sacroiliac Joint Dysfunction: 12-Month Outcomes. Neurosurgery 2015, 77: 674-691. PMID: 26291338, PMCID: PMC4605280, DOI: 10.1227/neu.0000000000000988.Peer-Reviewed Original ResearchConceptsTriangular titanium implantsQuality of lifeSacroiliac joint dysfunctionSurgical groupNonsurgical managementSIJ dysfunctionSIJ fusionJoint dysfunctionOswestry Disability Index improvementSix-month success rateInvasive Sacroiliac Joint FusionChronic SIJ dysfunctionInvasive SIJ fusionNonsurgical management groupsOswestry Disability IndexSacroiliac joint fusionLow back painRandomized Controlled TrialsLevel 1 studiesSuccess rateTitanium implantsDegenerative sacroiliitisSIJ disruptionDisability IndexSIJ painEvidence-Based Recommendations for Spine Surgery
Fisher CG, Vaccaro AR, Patel AA, Prasad SK, Chi J, Mulpuri K, Thomas KC, Whang PG. Evidence-Based Recommendations for Spine Surgery. Spine 2015, 40: e309-e316. PMID: 25901985, DOI: 10.1097/brs.0000000000000763.Peer-Reviewed Original ResearchSuperion Interspinous Process Spacer for Intermittent Neurogenic Claudication Secondary to Moderate Lumbar Spinal Stenosis
Patel VV, Whang PG, Haley TR, Bradley WD, Nunley PD, Davis RP, Miller LE, Block JE, Geisler FH. Superion Interspinous Process Spacer for Intermittent Neurogenic Claudication Secondary to Moderate Lumbar Spinal Stenosis. Spine 2015, 40: 275-282. PMID: 25494323, DOI: 10.1097/brs.0000000000000735.Peer-Reviewed Original ResearchConceptsLumbar spinal stenosisIntermittent neurogenic claudicationInterspinous process spacerNeurogenic claudicationClinical successSpinal stenosisModerate lumbar spinal stenosisPrimary composite endpointRate of complicationsMajority of patientsInvasive treatment alternativeConservative careLeg painSurgical decompressionControl patientsMost patientsComposite endpointNonsurgical managementHigh quality comparative dataPatient complaintsNoninferiority trialBACKGROUND DATAClaudicationInterspinous spacerPatients
2014
Evidence-Based Recommendations for Spine Surgery
Vaccaro AR, Fisher CG, Whang PG, Patel AA, Thomas KC, Mulpuri K, Chi J, Prasad SK. Evidence-Based Recommendations for Spine Surgery. Spine 2014, 39: e1183-e1189. PMID: 25166476, DOI: 10.1097/brs.0000000000000492.Peer-Reviewed Original ResearchTwo-year clinical outcomes of a multicenter randomized controlled trial comparing two interspinous spacers for treatment of moderate lumbar spinal stenosis
Patel VV, Whang PG, Haley TR, Bradley WD, Nunley PD, Miller LE, Block JE, Geisler FH. Two-year clinical outcomes of a multicenter randomized controlled trial comparing two interspinous spacers for treatment of moderate lumbar spinal stenosis. BMC Musculoskeletal Disorders 2014, 15: 221. PMID: 24996648, PMCID: PMC4109165, DOI: 10.1186/1471-2474-15-221.Peer-Reviewed Original ResearchMeSH KeywordsAgedBack PainDisability EvaluationEquipment DesignFemaleHumansLumbar VertebraeMaleOrthopedic ProceduresPain MeasurementPain, PostoperativePatient SatisfactionPredictive Value of TestsProspective StudiesRadiographyRecovery of FunctionSpinal StenosisSurveys and QuestionnairesTime FactorsTreatment OutcomeUnited StatesConceptsModerate lumbar spinal stenosisLumbar spinal stenosisConservative careInterspinous spacerClinical outcomesSpinal stenosisBack functionTwo-year clinical outcomesOswestry Disability IndexPhysical function scoresPatient-reported outcomesInvasive surgical alternativePatient satisfaction scoresExtremity painAxial painDisability IndexComplication dataFunction scoresSurgical alternativePatientsSatisfaction scoresSymptom severityPainIndex levelMulticenter
2013
Comparison of Axial and Anterior Interbody Fusions of the L5–S1 Segment
Whang PG, Sasso RC, Patel VV, Ali RM, Fischgrund JS. Comparison of Axial and Anterior Interbody Fusions of the L5–S1 Segment. Clinical Spine Surgery A Spine Publication 2013, 26: 437-443. PMID: 24196923, DOI: 10.1097/bsd.0b013e318292aad7.Peer-Reviewed Original ResearchConceptsAnterior lumbar interbody fusionAdverse eventsInterbody fusionPosterior fixationDevice-related adverse eventsL5-S1 interbody fusionL5-S1 disc spaceAnterior interbody fusionAnterior retroperitoneal approachSerious intraoperative complicationsAnterior column supportDifferent surgical approachesLumbar interbody fusionRadiographic fusion rateL5-S1 segmentSupplemental posterior fixationAxiaLIF techniqueHospital chartsIntraoperative complicationsMulticenter reviewRadiographic successRetroperitoneal approachArthrodesis ratesPresacral spaceProcedural dataRecovery Room Radiographs Not Found to Have Incremental Utility Above Intraoperative Images After Lumbar Fusion Procedures
Bohl DD, Gruskay JA, Miller CP, Varthi A, Ruiz FK, Whang PG, Grauer JN. Recovery Room Radiographs Not Found to Have Incremental Utility Above Intraoperative Images After Lumbar Fusion Procedures. Spine 2013, 38: 1927-1933. PMID: 23883831, DOI: 10.1097/brs.0b013e3182a527be.Peer-Reviewed Original ResearchConceptsLumbar fusion proceduresLumbar interbody fusionClinical utilityRecovery roomInterbody fusionFusion proceduresSurgical constructTransforaminal lumbar interbody fusionAnterior lumbar interbody fusionAnterior-posterior fusionRetrospective case seriesPosterolateral lumbar fusionLow clinical utilityPlain film imagesRecovery room radiographsIntraoperative imagesIncremental clinical utilityCase seriesConsecutive seriesLumbar fusionBACKGROUND DATAIntraoperative fluoroscopic imagesWound closureRadiation exposureIncremental utilityMitigating Adverse Event Reporting Bias in Spine Surgery
Auerbach JD, McGowan KB, Halevi M, Gerling MC, Sharan AD, Whang PG, Maislin G. Mitigating Adverse Event Reporting Bias in Spine Surgery. Journal Of Bone And Joint Surgery 2013, 95: 1450-1456. PMID: 23965694, DOI: 10.2106/jbjs.l.00251.Peer-Reviewed Original ResearchConceptsIndependent clinical events committeeClinical events committeeAdverse eventsClinical trialsLevels of severityInvestigational device exemption studyFuture clinical trialsAdverse event dataLumbar spinal fusionAdverse event reportingAdverse event reportsSpinal stenosisEvents committeeSafety profileSurgery StudyFusion groupInvestigator biasSpine surgerySpinal fusionSpine surgeonsSurgeryInvestigational deviceStudy sponsorEvent reportingFinancial interests