2008
Mutations Outside the Anisomycin-Binding Site Can Make Ribosomes Drug-Resistant
Blaha G, Gürel G, Schroeder SJ, Moore PB, Steitz TA. Mutations Outside the Anisomycin-Binding Site Can Make Ribosomes Drug-Resistant. Journal Of Molecular Biology 2008, 379: 505-519. PMID: 18455733, PMCID: PMC2442718, DOI: 10.1016/j.jmb.2008.03.075.Peer-Reviewed Original Research
2003
Structures of Five Antibiotics Bound at the Peptidyl Transferase Center of the Large Ribosomal Subunit
Hansen JL, Moore PB, Steitz TA. Structures of Five Antibiotics Bound at the Peptidyl Transferase Center of the Large Ribosomal Subunit. Journal Of Molecular Biology 2003, 330: 1061-1075. PMID: 12860128, DOI: 10.1016/s0022-2836(03)00668-5.Peer-Reviewed Original ResearchConceptsLarge ribosomal subunitPeptidyl transferase centerHydrophobic creviceRibosomal subunitP sitePeptide exit tunnelExit tunnelHaloarcula marismortuiP-loopPeptide bond formationAminoacyl-tRNAVirginiamycin MConformational changesBlasticidin SAntibiotics bindBindsSubunitsCompetitive inhibitorCrevicesSparsomycinTRNARibosomesMarismortui