2008
Mutations Outside the Anisomycin-Binding Site Can Make Ribosomes Drug-Resistant
Blaha G, Gürel G, Schroeder SJ, Moore PB, Steitz TA. Mutations Outside the Anisomycin-Binding Site Can Make Ribosomes Drug-Resistant. Journal Of Molecular Biology 2008, 379: 505-519. PMID: 18455733, PMCID: PMC2442718, DOI: 10.1016/j.jmb.2008.03.075.Peer-Reviewed Original Research
2007
The Structures of Antibiotics Bound to the E Site Region of the 50 S Ribosomal Subunit of Haloarcula marismortui: 13-Deoxytedanolide and Girodazole
Schroeder SJ, Blaha G, Tirado-Rives J, Steitz TA, Moore PB. The Structures of Antibiotics Bound to the E Site Region of the 50 S Ribosomal Subunit of Haloarcula marismortui: 13-Deoxytedanolide and Girodazole. Journal Of Molecular Biology 2007, 367: 1471-1479. PMID: 17321546, PMCID: PMC1925262, DOI: 10.1016/j.jmb.2007.01.081.Peer-Reviewed Original ResearchConceptsS ribosomal subunitEubacterial ribosomesEukaryotic ribosomesRibosomal subunitHaloarcula marismortuiE siteProtein synthesisSite regionProtein L28RibosomesConformational changesTRNAExtensive interactionsMarismortuiSubunitsStructure of antibioticsBindsSite componentsNew sitesArchaeaEubacteriaSitesL28Crystal structureL15
2002
A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits
Schmeing TM, Seila AC, Hansen JL, Freeborn B, Soukup JK, Scaringe SA, Strobel SA, Moore PB, Steitz TA. A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits. Nature Structural & Molecular Biology 2002, 9: 225-230. PMID: 11828326, DOI: 10.1038/nsb758.Peer-Reviewed Original Research