2021
Identification of Mg2+ ions next to nucleotides in cryo‐EM maps using electrostatic potential maps
Wang J, Natchiar SK, Moore PB, Klaholz BP. Identification of Mg2+ ions next to nucleotides in cryo‐EM maps using electrostatic potential maps. Acta Crystallographica Section D, Structural Biology 2021, 77: 534-539. PMID: 33825713, PMCID: PMC8025889, DOI: 10.1107/s2059798321001893.Peer-Reviewed Original Research
2009
U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics: The Structures of Tiamulin, Homoharringtonine, and Bruceantin Bound to the Ribosome
Gürel G, Blaha G, Moore PB, Steitz TA. U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics: The Structures of Tiamulin, Homoharringtonine, and Bruceantin Bound to the Ribosome. Journal Of Molecular Biology 2009, 389: 146-156. PMID: 19362093, PMCID: PMC2682339, DOI: 10.1016/j.jmb.2009.04.005.Peer-Reviewed Original ResearchConceptsSpecies specificityLarge ribosomal subunitPeptidyl transferase centerAmino acid side chainsHaloarcula marismortuiRibosomal subunitAcid side chainsSingle nucleotideNeighboring nucleotidesProtein synthesisRibosomesNucleotidesSide chainsMarismortuiInhibitorsSubunitsSpecificityInteractionComplexesA-siteHomoharringtonine
2008
Mutations Outside the Anisomycin-Binding Site Can Make Ribosomes Drug-Resistant
Blaha G, Gürel G, Schroeder SJ, Moore PB, Steitz TA. Mutations Outside the Anisomycin-Binding Site Can Make Ribosomes Drug-Resistant. Journal Of Molecular Biology 2008, 379: 505-519. PMID: 18455733, PMCID: PMC2442718, DOI: 10.1016/j.jmb.2008.03.075.Peer-Reviewed Original Research
2006
The Geometry of the Ribosomal Polypeptide Exit Tunnel
Voss NR, Gerstein M, Steitz TA, Moore PB. The Geometry of the Ribosomal Polypeptide Exit Tunnel. Journal Of Molecular Biology 2006, 360: 893-906. PMID: 16784753, DOI: 10.1016/j.jmb.2006.05.023.Peer-Reviewed Original Research
2005
The ribosome revealed
Moore PB, Steitz TA. The ribosome revealed. Trends In Biochemical Sciences 2005, 30: 281-283. PMID: 15950868, DOI: 10.1016/j.tibs.2005.04.006.Peer-Reviewed Original ResearchStructures of MLSBK Antibiotics Bound to Mutated Large Ribosomal Subunits Provide a Structural Explanation for Resistance
Tu D, Blaha G, Moore PB, Steitz TA. Structures of MLSBK Antibiotics Bound to Mutated Large Ribosomal Subunits Provide a Structural Explanation for Resistance. Cell 2005, 121: 257-270. PMID: 15851032, DOI: 10.1016/j.cell.2005.02.005.Peer-Reviewed Original ResearchConceptsLarge ribosomal subunitRibosomal subunitWild-type subunitsWild-type affinityResidue deletion mutantEubacterial ribosomesLarge subunitDeletion mutantsSubunitsResistance phenotypeStreptogramin AVirginiamycin SStructural explanationMutantsRibosomesA2058GAffinityL22BindsCrystal structurePhenotypeBinding
2004
The contribution of metal ions to the structural stability of the large ribosomal subunit
Klein DJ, Moore PB, Steitz TA. The contribution of metal ions to the structural stability of the large ribosomal subunit. RNA 2004, 10: 1366-1379. PMID: 15317974, PMCID: PMC1370624, DOI: 10.1261/rna.7390804.Peer-Reviewed Original ResearchConceptsLarge ribosomal subunitRibosomal subunitMonovalent cation binding siteNucleotide basesSpecific RNA structuresPeptidyl transferase centerLarge RNA moleculesPhylogenetic kingdomsRibosomal proteinsAppearance of proteinsRRNA structureHaloarcula marismortuiMajor groove sideEvolutionary periodRNA moleculesRNA structureCation binding siteStructural domainsTertiary structureProtein groupsMonovalent cationsBinding sitesRRNAGroove sideSubunits
2003
Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit
Schmeing TM, Moore PB, Steitz TA. Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit. RNA 2003, 9: 1345-1352. PMID: 14561884, PMCID: PMC1287056, DOI: 10.1261/rna.5120503.Peer-Reviewed Original ResearchStructures of Five Antibiotics Bound at the Peptidyl Transferase Center of the Large Ribosomal Subunit
Hansen JL, Moore PB, Steitz TA. Structures of Five Antibiotics Bound at the Peptidyl Transferase Center of the Large Ribosomal Subunit. Journal Of Molecular Biology 2003, 330: 1061-1075. PMID: 12860128, DOI: 10.1016/s0022-2836(03)00668-5.Peer-Reviewed Original ResearchConceptsLarge ribosomal subunitPeptidyl transferase centerHydrophobic creviceRibosomal subunitP sitePeptide exit tunnelExit tunnelHaloarcula marismortuiP-loopPeptide bond formationAminoacyl-tRNAVirginiamycin MConformational changesBlasticidin SAntibiotics bindBindsSubunitsCompetitive inhibitorCrevicesSparsomycinTRNARibosomesMarismortui
2002
The Structures of Four Macrolide Antibiotics Bound to the Large Ribosomal Subunit
Hansen JL, Ippolito JA, Ban N, Nissen P, Moore PB, Steitz TA. The Structures of Four Macrolide Antibiotics Bound to the Large Ribosomal Subunit. Molecular Cell 2002, 10: 117-128. PMID: 12150912, DOI: 10.1016/s1097-2765(02)00570-1.Peer-Reviewed Original ResearchA pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits
Schmeing TM, Seila AC, Hansen JL, Freeborn B, Soukup JK, Scaringe SA, Strobel SA, Moore PB, Steitz TA. A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits. Nature Structural & Molecular Biology 2002, 9: 225-230. PMID: 11828326, DOI: 10.1038/nsb758.Peer-Reviewed Original Research