Structural insights into peptide bond formation
Hansen JL, Schmeing TM, Moore PB, Steitz TA. Structural insights into peptide bond formation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 11670-11675. PMID: 12185246, PMCID: PMC129327, DOI: 10.1073/pnas.172404099.Peer-Reviewed Original ResearchConceptsP-site substrateBond formationHydrogen bondsSecond hydrogen bondPeptide bond formationCarbonyl carbonNucleophilic attackProduct analoguesAmino groupsAlpha-amino groupIntermediate analogueSubstrate complexStructural insightsP siteBondsSite substrateOHHaloarcula marismortui 50S ribosomal subunitAnaloguesSubstrateRibosomal subunitPresence of sparsomycinFormationP-loopComplexes