Structures of MLSBK Antibiotics Bound to Mutated Large Ribosomal Subunits Provide a Structural Explanation for Resistance
Tu D, Blaha G, Moore PB, Steitz TA. Structures of MLSBK Antibiotics Bound to Mutated Large Ribosomal Subunits Provide a Structural Explanation for Resistance. Cell 2005, 121: 257-270. PMID: 15851032, DOI: 10.1016/j.cell.2005.02.005.Peer-Reviewed Original ResearchConceptsLarge ribosomal subunitRibosomal subunitWild-type subunitsWild-type affinityResidue deletion mutantEubacterial ribosomesLarge subunitDeletion mutantsSubunitsResistance phenotypeStreptogramin AVirginiamycin SStructural explanationMutantsRibosomesA2058GAffinityL22BindsCrystal structurePhenotypeBinding