2006
Genomic aberrations are rare in urothelial neoplasms of patients 19 years or younger
Wild P, Giedl J, Stoehr R, Junker K, Boehm S, van Oers J, Zwarthoff E, Blaszyk H, Fine S, Humphrey P, Dehner L, Amin M, Epstein J, Hartmann A. Genomic aberrations are rare in urothelial neoplasms of patients 19 years or younger. The Journal Of Pathology 2006, 211: 18-25. PMID: 17072825, DOI: 10.1002/path.2075.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAlphapapillomavirusChildChild, PreschoolChromosome AberrationsChromosomes, Human, Pair 9DNA Mismatch RepairDNA Mutational AnalysisDNA, ViralFemaleGene Expression ProfilingGenes, p53HumansImmunohistochemistryIn Situ Hybridization, FluorescenceLoss of HeterozygosityMaleMicrosatellite InstabilityOligonucleotide Array Sequence AnalysisPapillomaPolymerase Chain ReactionReceptor, Fibroblast Growth Factor, Type 3Urologic NeoplasmsUrotheliumConceptsPatients 19 yearsUrothelial neoplasmsUrothelial papillomaMicrosatellite instabilityClinical outcomesHuman papillomavirusTP53 mutationsHigh-grade papillary urothelial carcinomaNIH consensus panelEvidence of diseaseFavorable clinical outcomeLow malignant potentialChromosome arm 9pPapillary urothelial carcinomaComparative genomic hybridizationPapillary urothelial neoplasmHPV positivityYounger patientsMultifocal tumorsUrothelial carcinomaUrothelial tumorsMalignant potentialPolymerase chain reactionConsensus panelKi-67
2000
Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association
Cook J, Hill D, Humphrey P, Pfeifer J, El-Mofty S. Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association. Modern Pathology 2000, 13: 914-918. PMID: 10955460, DOI: 10.1038/modpathol.3880164.Peer-Reviewed Original ResearchConceptsRecurrent respiratory papillomatosisSquamous cell carcinomaJuvenile-onset recurrent respiratory papillomatosisRespiratory papillomatosisCell carcinomaClinical featuresInvasive carcinomaHPV-11Malignant transformationFatal squamous cell carcinomaHuman papillomavirus typingHPV 11 DNASimilar clinical featuresYoung adult menPulmonary papillomaPulmonary involvementSquamous papillomaHPV typingBenign papillomasPapillomatosisSerotype associationCarcinomaAdult menPapillomasLung
1998
Lymphoid Lesions of the Gastrointestinal Tract: A Histologic, Immunophenotypic, and Genotypic Analysis of 49 Cases
O’Sullivan M, Ritter J, Humphrey P, Wick M. Lymphoid Lesions of the Gastrointestinal Tract: A Histologic, Immunophenotypic, and Genotypic Analysis of 49 Cases. American Journal Of Clinical Pathology 1998, 110: 471-477. PMID: 9763033, DOI: 10.1093/ajcp/110.4.471.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDAntigens, CD20Digestive SystemGastrointestinal NeoplasmsGene RearrangementGenotypeHumansImmunoglobulin Heavy ChainsImmunophenotypingKi-67 AntigenLeukemia, Lymphocytic, Chronic, B-CellLeukocyte Common AntigensLeukosialinLymphoid TissueLymphomaLymphoma, Large B-Cell, DiffusePolymerase Chain ReactionSialoglycoproteinsConceptsLymphoid infiltratesMalignant neoplasmsPolymerase chain reactionMalignant lesionsLow-grade malignant neoplasmAvailable diagnostic modalitiesLight microscopic criteriaParaffin-embedded specimensGenotypic analysisGI biopsy specimensConventional microscopic assessmentClinical evidenceClinical outcomesBiopsy specimensLymphoid lesionsCytologic atypiaImmunohistochemical stainsDiagnostic modalitiesGastrointestinal tractMonoclonal bandBenign lesionsDiagnostic standardEnd pointInfiltratesLesions
1997
Assessment of Clonality in Cutaneous Lymphoid Infiltrates by Polymerase Chain Reaction Analysis of Immunoglobulin Heavy Chain Gene Rearrangement
Ritter J, Wick M, Adesokan P, Fitzgibbon J, Zhu X, Humphrey P. Assessment of Clonality in Cutaneous Lymphoid Infiltrates by Polymerase Chain Reaction Analysis of Immunoglobulin Heavy Chain Gene Rearrangement. American Journal Of Clinical Pathology 1997, 108: 60-68. PMID: 9208979, DOI: 10.1093/ajcp/108.1.60.Peer-Reviewed Original ResearchConceptsCutaneous lymphoid infiltratesPolymerase chain reactionLymphoid infiltratesMonoclonal bandImmunoglobulin heavy chain geneFalse-positive resultsT cellsCell lymphomaB cellsValue of PCRLarge cell casesSparse perivascular infiltrateImmunoglobulin heavy chain gene rearrangementMixed cell lymphomaLarge cell lymphomaB-cell immunophenotypeHeavy chain gene rearrangementHeavy chain geneAssessment of clonalityChain gene rearrangementPerivascular infiltratesClinical featuresPolymerase chain reaction analysisClinical findingsMixed lesionsPrimitive Neuroectodermal Tumor of the Kidney-Another Enigma: a Pathologic, Immunohistochemical, and Molecular Diagnostic Study
Marley E, Liapis H, Humphrey P, Nadler R, Siegel C, Zhu X, Brandt J, Dehner L. Primitive Neuroectodermal Tumor of the Kidney-Another Enigma: a Pathologic, Immunohistochemical, and Molecular Diagnostic Study. The American Journal Of Surgical Pathology 1997, 21: 354-359. PMID: 9060607, DOI: 10.1097/00000478-199703000-00013.Peer-Reviewed Original ResearchConceptsPrimitive neuroectodermal tumorPolymerase chain reactionNeuroectodermal tumorRenal primitive neuroectodermal tumorPrimary primitive neuroectodermal tumorComplete immunohistochemical evaluationNeuron-specific enolasePrimitive round cellsDecades of lifeSoft tissue neoplasmSites of predilectionMolecular diagnostic studiesFormation of rosettesAbdominal painAbdominal massImmunohistochemical evaluationParaspinal regionEwing's sarcomaChest wallRound cellsTumor cellsCharacteristic translocationDiagnostic studiesProgenitor cellsKidney
1993
Mutation of the p53 tumor-suppressor gene is not a feature of endometrial hyperplasias
Kohler M, Nishii H, Humphrey P, Saski H, Marks J, Bast R, Clarke-Pearson D, Boyd J, Berchuck A. Mutation of the p53 tumor-suppressor gene is not a feature of endometrial hyperplasias. American Journal Of Obstetrics And Gynecology 1993, 169: 690-694. PMID: 8372881, DOI: 10.1016/0002-9378(93)90644-x.Peer-Reviewed Original Research
1992
Prevalence of human papillomavirus types 16 and 18 in squamous‐cell carcinoma of the penis: A retrospective analysis of primary and metastatic lesions by differential polymerase chain reaction
Wiener J, Effert P, Humphrey P, Yu L, Liu E, Walther P. Prevalence of human papillomavirus types 16 and 18 in squamous‐cell carcinoma of the penis: A retrospective analysis of primary and metastatic lesions by differential polymerase chain reaction. International Journal Of Cancer 1992, 50: 694-701. PMID: 1312062, DOI: 10.1002/ijc.2910500505.Peer-Reviewed Original ResearchConceptsHPV types 16Squamous cell carcinomaHPV 16Human papillomavirusType 16Metastatic sitesDifferential polymerase chain reactionHPV DNAMetastatic depositsHPV-18Polymerase chain reactionRetrospective analysisPresence of HPVType-specific HPV DNASeparate metastatic sitesCause-specific survivalHPV-negative groupKaplan-Meier analysisTumor histologic gradeHuman papillomavirus type 16Chain reactionPapillomavirus type 16Nodal involvementPatient ageHPV types