2022
Neighboring mutation‐mediated enhancement of dengue virus infectivity and spread
Chen L, Zhang X, Guo X, Peng W, Zhu Y, Wang Z, Yu X, Shi H, Li Y, Zhang L, Wang L, Wang P, Cheng G. Neighboring mutation‐mediated enhancement of dengue virus infectivity and spread. EMBO Reports 2022, 23: e55671. PMID: 36197120, PMCID: PMC9638853, DOI: 10.15252/embr.202255671.Peer-Reviewed Original Research
2016
Mosquito C-type lectins maintain gut microbiome homeostasis
Pang X, Xiao X, Liu Y, Zhang R, Liu J, Liu Q, Wang P, Cheng G. Mosquito C-type lectins maintain gut microbiome homeostasis. Nature Microbiology 2016, 1: 16023. PMID: 27170846, PMCID: PMC4861079, DOI: 10.1038/nmicrobiol.2016.23.Peer-Reviewed Original ResearchC-type lectinMammalian host immune systemHost immune systemAntimicrobial peptidesMajor mosquito vectorsCommensal bacteriaEvolutionary interactionsMultiple bacterial strainsSymbiotic bacteriaGut microbiomeGut microbial floraGut microbiome homeostasisFacilitate colonizationImmune systemGut commensal bacteriaMicrobial floraBacterial surfaceMicrobiome homeostasisAntagonistic relationshipBacterial strainsHomeostasisA. aegyptiMicrobiomeHost immune responseMosquito vectorsMosquito C-type lectins maintain gut microbiome homeostasis.
Pang X, Xiao X, Liu Y, Zhang R, Liu J, Liu Q, Wang P, Cheng G. Mosquito C-type lectins maintain gut microbiome homeostasis. Nature Microbiology 2016, 1: 16023. PMID: 27572642, DOI: 10.1038/nmicrobiol.2016.23.Peer-Reviewed Original ResearchConceptsC-type lectinMammalian host immune systemHost immune systemAntimicrobial peptidesMajor mosquito vectorsCommensal bacteriaEvolutionary interactionsMultiple bacterial strainsSymbiotic bacteriaGut microbiomeGut microbial floraGut microbiome homeostasisFacilitate colonizationImmune systemGut commensal bacteriaMicrobial floraBacterial surfaceMicrobiome homeostasisAntagonistic relationshipBacterial strainsHomeostasisA. aegyptiMicrobiomeHost immune responseMosquito vectors
2010
A C-Type Lectin Collaborates with a CD45 Phosphatase Homolog to Facilitate West Nile Virus Infection of Mosquitoes
Cheng G, Cox J, Wang P, Krishnan MN, Dai J, Qian F, Anderson JF, Fikrig E. A C-Type Lectin Collaborates with a CD45 Phosphatase Homolog to Facilitate West Nile Virus Infection of Mosquitoes. Cell 2010, 142: 714-725. PMID: 20797779, PMCID: PMC2954371, DOI: 10.1016/j.cell.2010.07.038.Peer-Reviewed Original ResearchConceptsWest Nile virusWNV infectionWest Nile virus infectionArthropod-borne flavivirusBlood-feeding processVirus infectionHuman CD45Viral disseminationC-type lectinInfectionViral entryViral attachmentMosquito homologCalcium-dependent mannerNile virusMolecular understandingVivo experimentsSame pathwayNatural vector