2020
Heterozygous/dispermic complete mole confers a significantly higher risk for post-molar gestational trophoblastic disease
Zheng XZ, Qin XY, Chen SW, Wang P, Zhan Y, Zhong PP, Buza N, Jin YL, Wu BQ, Hui P. Heterozygous/dispermic complete mole confers a significantly higher risk for post-molar gestational trophoblastic disease. Modern Pathology 2020, 33: 1979-1988. PMID: 32404958, DOI: 10.1038/s41379-020-0566-4.Peer-Reviewed Original ResearchConceptsNon-molar gestationsGestational trophoblastic diseaseTrophoblastic diseaseHigh riskGestational trophoblastic neoplasiaProducts of conceptionPatient demographicsClinical followClinical outcomesGynecology HospitalTrophoblastic neoplasiaBeijing ObstetricsFIGO criteriaChinese patientsClinical prognosisPatient managementLarge cohortGestationMolar gestationDiseaseGenetic abnormalitiesChromosomal monosomyChromosomal aneuploidyHydatidiformUniparental disomy
2019
Precision genotyping diagnosis of lung tumors with trophoblastic morphology in young women
Buza N, Baine I, Hui P. Precision genotyping diagnosis of lung tumors with trophoblastic morphology in young women. Modern Pathology 2019, 32: 1271-1280. PMID: 31028360, DOI: 10.1038/s41379-019-0275-z.Peer-Reviewed Original ResearchConceptsGestational choriocarcinomaLung carcinomaLung massClinical historyLung tumorsGestational originSerum beta-hCG levelsYoung womenTrophoblastic differentiationMetastatic gestational choriocarcinomaSerum beta-hCGBeta-hCG levelsEvidence of diseaseUnique diagnostic challengePrimary lung carcinomaGestational trophoblastic neoplasiaDifferent chemotherapeutic regimensDifferent primary sitesWedge resectionBeta-hCGFemale patientsMetastatic choriocarcinomaThird patientChemotherapeutic regimensImmunophenotypical features
2017
Hydatidiform Moles: Genetic Basis and Precision Diagnosis
Hui P, Buza N, Murphy KM, Ronnett BM. Hydatidiform Moles: Genetic Basis and Precision Diagnosis. Annual Review Of Pathology Mechanisms Of Disease 2017, 12: 449-485. PMID: 28135560, DOI: 10.1146/annurev-pathol-052016-100237.Peer-Reviewed Original Research
2016
Mucinous epithelial tumours arising from ovarian mature teratomas: a tissue genotyping study
Snir OL, Buza N, Hui P. Mucinous epithelial tumours arising from ovarian mature teratomas: a tissue genotyping study. Histopathology 2016, 69: 383-392. PMID: 26952875, DOI: 10.1111/his.12959.Peer-Reviewed Original ResearchConceptsOvarian mucinous tumorsMucinous borderline tumorsMucinous tumorsBorderline tumorsMucinous carcinomaAssociated teratomaPrimary ovarian mucinous tumorsOvarian mucinous borderline tumorMucinous epithelial tumorsOvarian mature teratomaGerm cell originShort tandem repeat polymorphic lociTissue genotypingMetastatic tumorsMature teratomaEpithelial tumorsTeratomatous componentsTumor originDiagnostic utilityMetastatic onesCell originTumorsTeratomaSomatic cellsPolymorphic lociA Comparison of the Roche Cobas HPV Test With the Hybrid Capture 2 Test for the Detection of High-Risk Human Papillomavirus Genotypes
Levi AW, Bernstein JI, Hui P, Duch K, Schofield K, Chhieng DC. A Comparison of the Roche Cobas HPV Test With the Hybrid Capture 2 Test for the Detection of High-Risk Human Papillomavirus Genotypes. Archives Of Pathology & Laboratory Medicine 2016, 140: 153-7. PMID: 26910220, DOI: 10.5858/arpa.2015-0027-oa.Peer-Reviewed Original ResearchConceptsHigh-risk human papillomavirusHuman papillomavirus assaysCobas human papillomavirus (HPV) testHigh-risk human papillomavirus DNAHybrid Capture 2 testHuman papillomavirus testingHuman papillomavirus testHuman papillomavirus DNAHuman papillomavirusPapillomavirus DNAHigh-risk human papillomavirus genotypesRoche cobas HPV testRoche CobasSurePath preparationsThinPrep specimensDiscordant resultsHybrid captureCobas HPV TestHuman papillomavirus resultsLiquid-based cytology samplesHybrid Capture 2Human papillomavirus genotypesLiquid-based preparationsHPV testCapture 2
2014
Egg Donor Pregnancy
Buza N, Hui P. Egg Donor Pregnancy. International Journal Of Gynecological Pathology 2014, 33: 507-510. PMID: 25083967, DOI: 10.1097/pgp.0b013e3182a1028b.Peer-Reviewed Original ResearchConceptsDonor pregnanciesMedical recordsClinical gestational ageFirst case reportPatients' medical recordsPositive nuclear stainingNormal staining patternVillous stromal cellsMaternal decidual tissuesDNA genotypingChorionic villous tissueGestational ageUnderwent dilationCase reportUterine contentsVillous tissueMorphologic featuresStromal cellsPregnancyStaining patternComplete hydatidiformPartial hydatidiformChorionic villiNuclear stainingMicroscopic evaluationGenotyping Diagnosis of Nongestational Choriocarcinoma Involving Fallopian Tube and Broad Ligament
Buza N, Rutherford T, Hui P. Genotyping Diagnosis of Nongestational Choriocarcinoma Involving Fallopian Tube and Broad Ligament. International Journal Of Gynecological Pathology 2014, 33: 58-63. PMID: 24300537, DOI: 10.1097/pgp.0b013e31827cd386.Peer-Reviewed Original ResearchConceptsBroad ligamentFallopian tubePelvic lymph node metastasisMultiagent chemotherapy regimenRecurrence 26 monthsRight adnexal massRight fallopian tubeLymph node metastasisOnly necrotic tissueLast menstrual periodLarge tumor massMicroscopic examinationChemotherapy regimenEctopic pregnancyMultiagent chemotherapyNongestational choriocarcinomaPure choriocarcinomaNode metastasisPatient ageInitial diagnosisInitial presentationGestational choriocarcinomaAdnexal massesFinal diagnosisEmergency room
2013
Tissue identity testing of cancer by short tandem repeat polymorphism: pitfalls of interpretation in the presence of microsatellite instability
Much M, Buza N, Hui P. Tissue identity testing of cancer by short tandem repeat polymorphism: pitfalls of interpretation in the presence of microsatellite instability. Human Pathology 2013, 45: 549-555. PMID: 24444463, DOI: 10.1016/j.humpath.2013.10.022.Peer-Reviewed Original ResearchAdaptor Proteins, Signal TransducingAdenocarcinomaAdenosine TriphosphatasesAdultAgedAged, 80 and overAllelesColorectal NeoplasmsDNA Mismatch RepairDNA Repair EnzymesDNA-Binding ProteinsEndometrial NeoplasmsEsophageal NeoplasmsFemaleGenetic LociGenotypeHumansMaleMicrosatellite InstabilityMicrosatellite RepeatsMiddle AgedMismatch Repair Endonuclease PMS2MutL Protein Homolog 1MutS Homolog 2 ProteinNuclear ProteinsPolymorphism, GeneticPartial Hydatidiform Mole
Buza N, Hui P. Partial Hydatidiform Mole. International Journal Of Gynecological Pathology 2013, 32: 307-315. PMID: 23518914, DOI: 10.1097/pgp.0b013e3182626011.Peer-Reviewed Original ResearchConceptsVillous sizeVillous hydropsMorphologic featuresHigh positive predictive valueCases of PHMSignificant histologic overlapPositive predictive valuePopulations of villusPartial Hydatidiform MoleCistern formationRoutine workupGynecologic pathologistsVillus sizeDefinitive diagnosisHistologic diagnosisHistologic findingsAvailable hematoxylinHistologic overlapDNA genotypingHistologic parametersEosin slidesPredictive valueDiagnostic significanceChromosomal trisomiesTrophoblastic hyperplasia
2012
BRAF V600E mutation in papillary thyroid microcarcinoma: a genotype–phenotype correlation
Virk RK, Van Dyke AL, Finkelstein A, Prasad A, Gibson J, Hui P, Theoharis CG, Carling T, Roman SA, Sosa JA, Udelsman R, Prasad ML. BRAF V600E mutation in papillary thyroid microcarcinoma: a genotype–phenotype correlation. Modern Pathology 2012, 26: 62-70. PMID: 22918165, DOI: 10.1038/modpathol.2012.152.Peer-Reviewed Original ResearchConceptsPapillary thyroid microcarcinomaThyroid microcarcinomaPapillary thyroid carcinomaFollicular variantThyroid carcinomaLateral cervical node metastasesOsteoclastic-type giant cellsCervical node metastasisInfiltrative tumor borderGroup of tumorsBRAF V600E mutationClassic nuclear featuresGenotype-phenotype correlationStromal calcificationLymphovascular invasionNode metastasisClinicopathologic featuresLymphocytic infiltrationAggressive featuresTumor sizeCystic changesPapillary microcarcinomaAbsence of mutationsHigh prevalenceMicrocarcinoma
2010
Molecular diagnosis of gestational trophoblastic disease
Hui P. Molecular diagnosis of gestational trophoblastic disease. Expert Review Of Molecular Diagnostics 2010, 10: 1023-1034. PMID: 21080819, DOI: 10.1586/erm.10.93.Peer-Reviewed Original ResearchGlial Heterotopia of the Uterine Cervix: DNA Genotyping Confirmation of its Fetal Origin
Siddon A, Hui P. Glial Heterotopia of the Uterine Cervix: DNA Genotyping Confirmation of its Fetal Origin. International Journal Of Gynecological Pathology 2010, 29: 394-397. PMID: 20567155, DOI: 10.1097/pgp.0b013e3181c5a7e8.Peer-Reviewed Original ResearchConceptsGlial heterotopiaUterine cervixGlial tissueKlinefelter syndromeFetal originGlial fibrillary acidic proteinMature glial tissueFibrillary acidic proteinDown syndrome fetusesFetal brain tissueEndocervical glandular epitheliumFetal tissue samplesS100 immunohistochemistryCervical polypsCervical lesionsElective terminationIntriguing lesionsPregnancy terminationIdentical genetic profilesSyndrome fetusesGlandular epitheliumSyndromeBrain tissueFirst gestationDown syndrome
2008
Epithelioid trophoblastic tumor: comparative genomic hybridization and diagnostic DNA genotyping
Xu ML, Yang B, Carcangiu ML, Hui P. Epithelioid trophoblastic tumor: comparative genomic hybridization and diagnostic DNA genotyping. Modern Pathology 2008, 22: 232-238. PMID: 18820674, DOI: 10.1038/modpathol.2008.165.Peer-Reviewed Original ResearchMeSH KeywordsAdultCarcinoma, Squamous CellComparative Genomic HybridizationDiagnosis, DifferentialEndometrial NeoplasmsEpithelioid CellsFemaleGene Expression Regulation, NeoplasticGenetic TestingGenotypeGestational Trophoblastic DiseaseHumansItalyLung NeoplasmsMiddle AgedPregnancyUnited StatesUterine Cervical NeoplasmsConceptsEpithelioid trophoblastic tumorTrophoblastic tumorSquamous cell carcinomaUterine cervixComparative genomic hybridizationCommon squamous cell carcinomaChromosomal alterationsInvasive squamous cell carcinomaChorionic-type intermediate trophoblastGestational trophoblastic diseaseGenomic hybridizationDNA genotypingIntermediate trophoblastTrophoblastic diseaseAnatomic locationComparative genomic hybridization analysisTrophoblastic originTumorsGenomic hybridization analysisCervixNormal tissuesTrophoblastic natureConventional comparative genomic hybridizationCarcinomaChromosomal profileGenotypic Analysis of Hydatidiform Mole: An Accurate and Practical Method of Diagnosis
Bifulco C, Johnson C, Hao L, Kermalli H, Bell S, Hui P. Genotypic Analysis of Hydatidiform Mole: An Accurate and Practical Method of Diagnosis. The American Journal Of Surgical Pathology 2008, 32: 445-451. PMID: 18300805, DOI: 10.1097/pas.0b013e3181520034.Peer-Reviewed Original ResearchConceptsMolar pregnancyMaternal endometrial tissuesDaily clinical practiceDNA ploidy analysisDNA genotypingCases of HMUnstained paraffin sectionsHistologic featuresEndometrial tissueMorphologic mimicsClinical practiceMolar gestationHydatidiform MoleParaffin sectionsChorionic villiDiagnosisRoutine diagnosisPregnancyPloidy analysisGenotypic analysisGenotypingPaternal originPCR amplification systemGestationCasesPrimary or Secondary? Genotyping Confirmation of an Ovarian Primary Carcinoid Tumor
Dotto J, Mezzetti T, Hui P. Primary or Secondary? Genotyping Confirmation of an Ovarian Primary Carcinoid Tumor. International Journal Of Gynecological Pathology 2008, 27: 33-36. PMID: 18156971, DOI: 10.1097/pgp.0b13e318053df4.Peer-Reviewed Original ResearchConceptsPrimary carcinoid tumorCarcinoid tumorsGerm cell originCell originInsular carcinoid tumorPure histological typePrimary ovarian tumorsSignificant diagnostic challengeExtraovarian tumorMetastatic carcinoidLymphovascular invasionHistological typeOvarian tumorsMetastatic tumorsClinical managementDiagnostic challengeTeratomatous componentsGastrointestinal tractTumorsAdditional studiesDNA genotypingCarcinoidsPrognosisTractWomen
2007
Absence of Y chromosome in human placental site trophoblastic tumor
Hui P, Wang HL, Chu P, Yang B, Huang J, Baergen RN, Sklar J, Yang XJ, Soslow RA. Absence of Y chromosome in human placental site trophoblastic tumor. Modern Pathology 2007, 20: 1055-1060. PMID: 17643092, DOI: 10.1038/modpathol.3800941.Peer-Reviewed Original Research