2013
Tall Cell Variant of Papillary Thyroid Microcarcinoma: Clinicopathologic Features with BRAFV600E Mutational Analysis
Bernstein J, Virk RK, Hui P, Prasad A, Westra WH, Tallini G, Adeniran AJ, Udelsman R, Sasaki CT, Roman SA, Sosa JA, Prasad ML. Tall Cell Variant of Papillary Thyroid Microcarcinoma: Clinicopathologic Features with BRAFV600E Mutational Analysis. Thyroid 2013, 23: 1525-1531. PMID: 23682579, DOI: 10.1089/thy.2013.0154.Peer-Reviewed Original ResearchConceptsTall cell variantPapillary thyroid microcarcinomaPapillary microcarcinomaCell variantLymphovascular invasionNode metastasisThyroid microcarcinomaAdvanced stageCentral compartment lymph node metastasisLateral cervical node metastasesStage III/IVACentral compartment lymph nodesLateral cervical nodesMultifocal papillary carcinomaLymph node dissectionCervical node metastasisLymph node metastasisPapillary thyroid carcinomaNode dissectionTotal thyroidectomyCervical nodesLymph nodesClinicopathologic featuresMultifocal tumorsAggressive features
2012
BRAF V600E mutation in papillary thyroid microcarcinoma: a genotype–phenotype correlation
Virk RK, Van Dyke AL, Finkelstein A, Prasad A, Gibson J, Hui P, Theoharis CG, Carling T, Roman SA, Sosa JA, Udelsman R, Prasad ML. BRAF V600E mutation in papillary thyroid microcarcinoma: a genotype–phenotype correlation. Modern Pathology 2012, 26: 62-70. PMID: 22918165, DOI: 10.1038/modpathol.2012.152.Peer-Reviewed Original ResearchConceptsPapillary thyroid microcarcinomaThyroid microcarcinomaPapillary thyroid carcinomaFollicular variantThyroid carcinomaLateral cervical node metastasesOsteoclastic-type giant cellsCervical node metastasisInfiltrative tumor borderGroup of tumorsBRAF V600E mutationClassic nuclear featuresGenotype-phenotype correlationStromal calcificationLymphovascular invasionNode metastasisClinicopathologic featuresLymphocytic infiltrationAggressive featuresTumor sizeCystic changesPapillary microcarcinomaAbsence of mutationsHigh prevalenceMicrocarcinomaPapillary thyroid carcinomas with and without BRAF V600E mutations are morphologically distinct
Finkelstein A, Levy GH, Hui P, Prasad A, Virk R, Chhieng DC, Carling T, Roman SA, Sosa JA, Udelsman R, Theoharis CG, Prasad ML. Papillary thyroid carcinomas with and without BRAF V600E mutations are morphologically distinct. Histopathology 2012, 60: 1052-1059. PMID: 22335197, DOI: 10.1111/j.1365-2559.2011.04149.x.Peer-Reviewed Original Research
2011
BRAF Mutation Testing of Thyroid Fine-Needle Aspiration Specimens Enhances the Predictability of Malignancy in Thyroid Follicular Lesions of Undetermined Significance
Adeniran AJ, Hui P, Chhieng DC, Prasad ML, Schofield K, Theoharis C. BRAF Mutation Testing of Thyroid Fine-Needle Aspiration Specimens Enhances the Predictability of Malignancy in Thyroid Follicular Lesions of Undetermined Significance. Acta Cytologica 2011, 55: 570-575. PMID: 22156468, DOI: 10.1159/000333274.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiopsy, Fine-NeedleCarcinomaCarcinoma, PapillaryCell Transformation, NeoplasticDNA Mutational AnalysisFemaleHumansMaleMiddle AgedPractice Guidelines as TopicPredictive Value of TestsPrognosisProto-Oncogene Proteins B-rafRiskTerminology as TopicThyroid Cancer, PapillaryThyroid GlandThyroid NeoplasmsThyroid NoduleConceptsPapillary thyroid carcinomaBRAF mutation analysisBRAF mutationsUndetermined significanceFollicular lesionsUndetermined significance/follicular lesionFine needle aspiration cytology specimensAUS/FLUS categoryMutation analysisBRAF-positive casesIndeterminate thyroid FNAsAspiration cytology specimensRisk of malignancySurgical pathology outcomeFine-needle aspiration specimensBRAF mutation testingNegative predictive valueSurgical pathology reportsThyroid follicular lesionsPredictability of malignancyThyroid fine-needle aspiration specimensSurgical interventionFinal diagnosisPathology outcomesPathology reportsReflex BRAF Testing in Thyroid Fine-Needle Aspiration Biopsy with Equivocal and Positive Interpretation: A Prospective Study
Adeniran AJ, Theoharis C, Hui P, Prasad ML, Hammers L, Carling T, Udelsman R, Chhieng DC. Reflex BRAF Testing in Thyroid Fine-Needle Aspiration Biopsy with Equivocal and Positive Interpretation: A Prospective Study. Thyroid 2011, 21: 717-723. PMID: 21568726, DOI: 10.1089/thy.2011.0021.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBiomarkers, TumorBiopsy, Fine-NeedleCarcinomaCarcinoma, PapillaryChildDNA Mutational AnalysisFemaleHumansMaleMiddle AgedPoint MutationPolymorphism, Single-Stranded ConformationalProspective StudiesProto-Oncogene Proteins B-rafThyroid Cancer, PapillaryThyroid GlandThyroid Neoplasms
2005
BRAF Mutation Predicts a Poorer Clinical Prognosis for Papillary Thyroid Cancer
Xing M, Westra WH, Tufano RP, Cohen Y, Rosenbaum E, Rhoden KJ, Carson KA, Vasko V, Larin A, Tallini G, Tolaney S, Holt EH, Hui P, Umbricht CB, Basaria S, Ewertz M, Tufaro AP, Califano JA, Ringel MD, Zeiger MA, Sidransky D, Ladenson PW. BRAF Mutation Predicts a Poorer Clinical Prognosis for Papillary Thyroid Cancer. The Journal Of Clinical Endocrinology & Metabolism 2005, 90: 6373-6379. PMID: 16174717, DOI: 10.1210/jc.2005-0987.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerBRAF mutation statusBRAF mutationsClinicopathological predictorsRisk stratificationClinicopathological outcomesThyroid cancerPTC subtypesMutation statusTumor stage III/IVStage I/II diseaseMultivariate analysisTumor BRAF mutation statusStage III/IVInitial tumor characteristicsLymph node metastasisPoor clinicopathological outcomesInitial surgeryRecurrent diseaseClinical courseIndependent predictorsNode metastasisClinicopathological characteristicsSubsequent recurrenceTreatment failure
2002
Assessment of RET/PTC Oncogene Activation and Clonality in Thyroid Nodules with Incomplete Morphological Evidence of Papillary Carcinoma A Search for the Early Precursors of Papillary Cancer
Fusco A, Chiappetta G, Hui P, Garcia-Rostan G, Golden L, Kinder BK, Dillon DA, Giuliano A, Cirafici AM, Santoro M, Rosai J, Tallini G. Assessment of RET/PTC Oncogene Activation and Clonality in Thyroid Nodules with Incomplete Morphological Evidence of Papillary Carcinoma A Search for the Early Precursors of Papillary Cancer. American Journal Of Pathology 2002, 160: 2157-2167. PMID: 12057919, PMCID: PMC1850819, DOI: 10.1016/s0002-9440(10)61164-9.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsBase SequenceCarcinoma, PapillaryCloning, MolecularDrosophila ProteinsGene Expression Regulation, NeoplasticGenetic MarkersHumansMembrane ProteinsMiceMolecular Sequence DataNeoplasm InvasivenessNuclear Receptor CoactivatorsOncogene ProteinsOncogene Proteins, FusionPatched ReceptorsPatched-1 ReceptorProtein-Tyrosine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-retRabbitsReceptor Protein-Tyrosine KinasesReceptors, Cell SurfaceReverse Transcriptase Polymerase Chain ReactionThyroid NeoplasmsThyroid NoduleTranscription FactorsConceptsLaser capture microdissectionPapillary cancerRET/PTC1RET immunoreactivityThyroid nodulesCarcinoma featuresMicroscopic fociPapillary carcinomaInvasive papillary cancerCytological alterationsReverse transcriptase-polymerase chain reactionRET activationRET/PTC3 rearrangementsTranscriptase-polymerase chain reactionRET/PTC3Analysis of clonalityRET/PTC oncogene activationPrecursor lesionsEntire lesionTumor fociPolyclonal tumorsAdenomatous nodulesMorphological changesSame tumorMorphological signs