2024
Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147)
Sheth S, Oh J, Bellone S, Siegel E, Greenman M, Mutlu L, McNamara B, Pathy S, Clark M, Azodi M, Altwerger G, Andikyan V, Huang G, Ratner E, Kim D, Iwasaki A, Levi A, Buza N, Hui P, Flaherty S, Schwartz P, Santin A. Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147). Clinical Cancer Research 2024, 30: of1-of10. PMID: 38592381, DOI: 10.1158/1078-0432.ccr-23-3639.Peer-Reviewed Original ResearchConceptsRandomized phase II trialCD4/CD8 T cellsT cellsHPV clearanceArm BNo significant differenceClinical surveillanceRate of HPV clearanceSecondary outcomesPre-neoplastic cervical lesionsCervical intraepithelial neoplasiaT cell infiltrationT cell responsesSignificant differenceCIN3 patientsIntraepithelial neoplasiaArm ACervical lesionsImiquimod groupSurveillance armVaginal suppositoriesProspective trialsArm CHPV vaccinationImiquimod
2013
Frequent KRAS mutation in complex mucinous epithelial lesions of the endometrium
Alomari A, Abi-Raad R, Buza N, Hui P. Frequent KRAS mutation in complex mucinous epithelial lesions of the endometrium. Modern Pathology 2013, 27: 675-680. PMID: 24186144, DOI: 10.1038/modpathol.2013.186.Peer-Reviewed Original ResearchConceptsPositive predictive valueMucinous lesionsKRAS mutationsMucinous changeMucinous adenocarcinomaEndometrial mucinous carcinomaHigh positive predictive valueComplex atypical hyperplasiaRisk stratification algorithmAtypical complex hyperplasiaImportant prognostic indicatorFrequent KRAS mutationsKRAS mutation analysisComplex hyperplasiaHysterectomy specimensClinical progressionEndometrial lesionsMucinous carcinomaAtypical hyperplasiaPrognostic indicatorMucinous differentiationEpithelial lesionsCurettage casesStratification algorithmPredictive value
2001
Bloom Syndrome in Sibs: First Reports of Hepatocellular Carcinoma and Wilms Tumor with Documented Anaplasia and Nephrogenic Rests
Jain D, Hui P, McNamara J, Schwartz D, German J, Reyes-Múgica M. Bloom Syndrome in Sibs: First Reports of Hepatocellular Carcinoma and Wilms Tumor with Documented Anaplasia and Nephrogenic Rests. Pediatric And Developmental Pathology 2001, 4: 585-589. PMID: 11826367, DOI: 10.1007/s10024001-0082-6.Peer-Reviewed Original Research