2004
Roles of the Proline-rich Domain in SLP-76 Subcellular Localization and T Cell Function* [boxs]
Singer AL, Bunnell SC, Obstfeld AE, Jordan MS, Wu JN, Myung PS, Samelson LE, Koretzky GA. Roles of the Proline-rich Domain in SLP-76 Subcellular Localization and T Cell Function* [boxs]. Journal Of Biological Chemistry 2004, 279: 15481-15490. PMID: 14722089, DOI: 10.1074/jbc.m313339200.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAlanineAntigens, CDAntigens, Differentiation, T-LymphocyteArginineBlotting, WesternCalciumCell LineCell LineageFlow CytometryGene DeletionGenes, DominantHematopoietic Stem CellsHumansJurkat CellsLectins, C-TypeLuciferasesLymphocyte ActivationLysineMembrane MicrodomainsModels, BiologicalMutationPhosphoproteinsPlasmidsPrecipitin TestsProlineProtein Structure, TertiarySignal TransductionSrc Homology DomainsSubcellular FractionsTime FactorsT-LymphocytesTransfectionConceptsSLP-76P1 domainSLP-76 functionProline-rich domainProline-rich regionDomain deletion mutantMultiple hematopoietic lineagesLeukocyte-specific phosphoproteinSrc homologyDeletion mutantsSignal transductionSubcellular localizationHematopoietic lineagesFunctional roleProtein fragmentsT cell receptorMolecular scaffoldsCell functionCell receptorLocalizationComplementary approachesDomainT cell functionMolecular associationDirect evidence
2001
Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells
Allman D, Karnell F, Punt J, Bakkour S, Xu L, Myung P, Koretzky G, Pui J, Aster J, Pear W. Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells. Journal Of Experimental Medicine 2001, 194: 99-106. PMID: 11435476, PMCID: PMC2193437, DOI: 10.1084/jem.194.1.99.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone MarrowCell LineageDNA-Binding ProteinsHematopoietic Stem CellsHyaluronan ReceptorsLeukemia, T-CellMembrane ProteinsMiceMice, TransgenicReceptor, Notch1Receptors, Antigen, T-Cell, alpha-betaReceptors, Cell SurfaceReceptors, Interleukin-2Signal TransductionThymus GlandT-LymphocytesTranscription FactorsConceptsT lineage commitmentT cell developmentHematopoietic stem cellsLineage commitmentCell developmentSrc homology 2 domainPre-T cell receptorBone marrowT cell-specific signalsBM transferT cellsCell-specific signalsMultipotent progenitor cellsDouble-positive T cellsTCR-beta transgeneLeukocyte proteinBM cell populationsFunction of Notch1T-cell leukemiaLater time pointsCD3 epsilonActive Notch1Beta transgeneBM cellsCell leukemia