Trends in C-Reactive Protein, D-Dimer, and Fibrinogen during Therapy for HIV-Associated Multidrug-Resistant Tuberculosis.
Cudahy PGT, Warren JL, Cohen T, Wilson D. Trends in C-Reactive Protein, D-Dimer, and Fibrinogen during Therapy for HIV-Associated Multidrug-Resistant Tuberculosis. American Journal Of Tropical Medicine And Hygiene 2018, 99: 1336-1341. PMID: 30226135, PMCID: PMC6221241, DOI: 10.4269/ajtmh.18-0322.Peer-Reviewed Original ResearchConceptsC-reactive proteinMulti-drug resistant tuberculosisD-dimerMedian C-reactive proteinSerum C-reactive proteinHigher baseline fibrinogenMDR-TB therapyHIV-positive adultsDrug-resistant tuberculosisHIV-positive participantsHigher CRP concentrationsEarly treatment modificationBaseline fibrinogenTreatment initiationResistant tuberculosisCRP concentrationsTreatment modificationTreatment outcomesTreatment responseHigh riskHigh mortalityNormal levelsOlder ageEarly responseFibrinogenEvaluation of Tuberculosis Treatment Response With Serial C-Reactive Protein Measurements
Wilson D, Moosa MS, Cohen T, Cudahy P, Aldous C, Maartens G. Evaluation of Tuberculosis Treatment Response With Serial C-Reactive Protein Measurements. Open Forum Infectious Diseases 2018, 5: ofy253. PMID: 30474046, PMCID: PMC6240901, DOI: 10.1093/ofid/ofy253.Peer-Reviewed Original ResearchC-reactive proteinTuberculosis groupAntituberculosis therapyWeek 2Serial C-reactive protein measurementsC-reactive protein measurementTuberculosis treatment responseNegative sputum smearsSmear-negative patientsSmear-negative tuberculosisSymptoms of tuberculosisMedian weight gainCohort of adultsNegative predictive valueAntituberculosis treatmentCRP reductionHIV testingHIV prevalenceAdverse outcomesSputum smearHemoglobin increaseSerial changesWeek 8Treatment responseBaseline values