Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice
Michael HT, Graff-Cherry C, Chin S, Rauck C, Habtemichael AD, Bunda P, Smith T, Campos MM, Bharti K, Arnheiter H, Merlino G, Day CP. Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice. Investigative Ophthalmology & Visual Science 2018, 59: 6067-6073. PMID: 30590377, PMCID: PMC6314104, DOI: 10.1167/iovs.18-25186.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternChoroidEctopic Gene ExpressionEmbryonic DevelopmentFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalGenotyping TechniquesImmunohistochemistryIntramolecular OxidoreductasesIrisMaleMelanocytesMiceMice, Inbred C57BLMice, TransgenicMicrophthalmia-Associated Transcription FactorMicrophthalmosRetinal Pigment EpitheliumReverse Transcriptase Polymerase Chain ReactionSkinConceptsMicrophthalmia transcription factorMITF-M expressionEctopic expressionEpithelium gene expressionRetinal dysplasiaNew mouse lineMouse eyeRetinal structureCutaneous melanocytesRPE structureUveal melanocytesRPE functionMiceMouse linesComplete deficiencyPigmentary genesInducible ectopic expressionMelanocytesMITF isoformsIris melanocytesMicrophthalmiaPhenotypic abnormalitiesEyesMITFPartial rescue