Hypothalamic oestrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure
van Veen JE, Kammel LG, Bunda PC, Shum M, Reid MS, Massa MG, Arneson D, Park JW, Zhang Z, Joseph AM, Hrncir H, Liesa M, Arnold AP, Yang X, Correa SM. Hypothalamic oestrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure. Nature Metabolism 2020, 2: 351-363. PMID: 32377634, PMCID: PMC7202561, DOI: 10.1038/s42255-020-0189-6.Peer-Reviewed Original ResearchConceptsFemale-biased expressionMale-biased expressionSex-biased expressionSingle-cell RNA transcriptomicsPrecise neuronal populationsEstrogen receptor alphaReceptor alphaGene functionVentromedial hypothalamusRegulatory nodesRNA transcriptomicsMale developmentNeuronal populationsMouse ventromedial hypothalamusSitu hybridizationEnergy homeostasisEnergy expenditureCore temperatureExpressionTachykinin-1RPRMReduced core temperatureVMH neuronsChemogenetic activationPhysical activity