AMPK-mediated potentiation of GABAergic signalling drives hypoglycaemia-provoked spike-wave seizures
Salvati KA, Ritger ML, Davoudian PA, O'Dell F, Wyskiel DR, Souza GMPR, Lu AC, Perez-Reyes E, Drake JC, Yan Z, Beenhakker MP. AMPK-mediated potentiation of GABAergic signalling drives hypoglycaemia-provoked spike-wave seizures. Brain 2022, 145: 2332-2346. PMID: 35134125, PMCID: PMC9337815, DOI: 10.1093/brain/awac037.Peer-Reviewed Original ResearchConceptsSpike-wave seizuresAbsence epilepsyGABAB receptor functionThalamic brain slicesThalamocortical neuronsCircuit excitabilitySystemic administrationBrain slicesRodent modelsNeuronal activityDiabetes treatmentEpileptic seizuresSeizuresProtein kinaseProtein kinase activationAMPEpilepsyNetwork activityKinase activationMetabolismActivationProtein kinase agonistsEnergetic stressHypoglycaemiaKinase