MicroRNA-124 expression counteracts pro-survival stress responses in glioblastoma
Mucaj V, Lee S, Skuli N, Giannoukos D, Qiu B, Eisinger-Mathason T, Nakazawa M, Shay J, Gopal P, Venneti S, Lal P, Minn A, Simon M, Mathew L. MicroRNA-124 expression counteracts pro-survival stress responses in glioblastoma. Oncogene 2014, 34: 2204-2214. PMID: 24954504, PMCID: PMC4275412, DOI: 10.1038/onc.2014.168.Peer-Reviewed Original ResearchConceptsMiR-124 expressionMiR-124 levelsGlioblastoma patient samplesTumor cell survivalPatient samplesAggressive adult brain tumorCell survivalCell deathSurvival of miceAdult brain tumorsHypoxic gene signaturePoor patient outcomesIntracranial xenograft tumorsHypoxic cell deathIncreases cell deathPatient outcomesTumor ischemiaXenograft tumorsBrain tumorsGlioblastoma patientsIschemic regionTherapeutic resistanceTumor progressionCancer typesGene signature