2022
Prophylactic Use of Antifibrinolytics During Pediatric Cardiac Surgery With Cardiopulmonary Bypass on Postoperative Bleeding and Transfusion: A Systematic Review and Meta-Analysis
Schertz K, Karam O, Demetres M, Mayadunna S, Faraoni D, Nellis ME. Prophylactic Use of Antifibrinolytics During Pediatric Cardiac Surgery With Cardiopulmonary Bypass on Postoperative Bleeding and Transfusion: A Systematic Review and Meta-Analysis. Pediatric Critical Care Medicine 2022, 23: e517-e529. PMID: 35997516, DOI: 10.1097/pcc.0000000000003049.Peer-Reviewed Original ResearchConceptsChest tube outputQuality of evidenceCardiopulmonary bypassTranexamic acidCardiac surgeryMean decreaseTube outputPlatelet requirementsPlatelet transfusionsML/P-valueMeta-AnalysisSystematic reviewStandardized data extraction toolBlood product requirementsPediatric cardiac surgeryPlasma requirementsPreferred Reporting ItemsData extraction toolWeb of SciencePostoperative bleedingCyanotic patientsPlasma transfusionBlood lossRBC transfusionWhat Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding
Delaney M, Karam O, Lieberman L, Steffen K, Muszynski JA, Goel R, Bateman ST, Parker RI, Nellis ME, Remy KE, Network A. What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding. Pediatric Critical Care Medicine 2022, 23: e1-e13. PMID: 34989701, PMCID: PMC8769352, DOI: 10.1097/pcc.0000000000002854.Peer-Reviewed Original ResearchConceptsAnemia EXpertise Initiative-Control/AvoidanceIll pediatric patientsIll childrenPlasma transfusionPediatric patientsPlatelet transfusionsConsensus statementSystematic reviewLos Angeles Appropriateness MethodPhysiologic triggerExpert-based statementsCritically Ill ChildrenDevelopment/UniversityExpert consensus statementCochrane Library databasesBleeding expertsRecommendations AssessmentTransfusion managementAppropriateness MethodBlood productsLaboratory testingTransfusionLibrary databasesConsensus conferenceExpert consensusPlasma and Platelet Transfusion Strategies in Critically Ill Children With Malignancy, Acute Liver Failure and/or Liver Transplantation, or Sepsis: From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding
Lieberman L, Karam O, Stanworth SJ, Goobie SM, Crighton G, Goel R, Lacroix J, Nellis ME, Parker RI, Steffen K, Stricker P, Valentine SL, Steiner ME, Network A. Plasma and Platelet Transfusion Strategies in Critically Ill Children With Malignancy, Acute Liver Failure and/or Liver Transplantation, or Sepsis: From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding. Pediatric Critical Care Medicine 2022, 23: e37-e49. PMID: 34989704, PMCID: PMC8769367, DOI: 10.1097/pcc.0000000000002857.Peer-Reviewed Original ResearchConceptsAnemia EXpertise Initiative-Control/AvoidanceAcute liver diseaseLiver transplantationExpert consensus statementLiver diseaseIntravascular coagulationIll neonatesPlatelet transfusionsIll childrenConsensus statementSystematic reviewLos Angeles Appropriateness MethodExpert-based statementsAcute liver failurePlatelet transfusion strategyDevelopment/UniversityCochrane Library databasesBleeding expertsRecommendations AssessmentTransfusion strategyLiver failureTransfusion managementAppropriateness MethodTransfusionSepsis
2021
Transfusion management for children supported by extracorporeal membrane oxygenation
Karam O, Nellis ME. Transfusion management for children supported by extracorporeal membrane oxygenation. Transfusion 2021, 61: 660-664. PMID: 33491189, DOI: 10.1111/trf.16272.Peer-Reviewed Original Research
2020
Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines.
Nellis ME, Saini A, Spinella PC, Davis PJ, Steiner ME, Tucci M, Cushing M, Demaret P, Stanworth SJ, Leteurtre S, Karam O. Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines. Pediatric Critical Care Medicine 2020, 21: 267-275. PMID: 31644453, PMCID: PMC7060816, DOI: 10.1097/pcc.0000000000002160.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood TransfusionChildChild, PreschoolExtracorporeal Membrane OxygenationFemaleHemorrhageHumansInfantInfant, NewbornIntensive Care Units, PediatricInternational Normalized RatioMalePlasmaPlatelet CountPlatelet TransfusionPractice Guidelines as TopicProspective StudiesSurveys and QuestionnairesConceptsExtracorporeal membrane oxygenationMembrane oxygenationPlatelet transfusionsTotal platelet countPlasma transfusionPlatelet countSubgroup analysisInstitutional protocolMedian increaseInternational point prevalence studyPediatric extracorporeal membrane oxygenationTotal median doseInternational normalized ratioML/Point prevalence studyPlatelet count valuesScreening weekMedian doseMild coagulopathyNormalized ratioInterventional studyLocal guidelinesObservational studyMedian reductionTransfusion
2017
Outcomes Related to the Use of Frozen Plasma or Pooled Solvent/Detergent-Treated Plasma in Critically Ill Children*
Camazine MN, Karam O, Colvin R, Leteurtre S, Demaret P, Tucci M, Muszynski JA, Stanworth S, Spinella PC. Outcomes Related to the Use of Frozen Plasma or Pooled Solvent/Detergent-Treated Plasma in Critically Ill Children*. Pediatric Critical Care Medicine 2017, 18: e215-e223. PMID: 28350560, DOI: 10.1097/pcc.0000000000001149.Peer-Reviewed Original ResearchConceptsSolvent detergent plasmaPlasma 24 hoursICU mortalityIll childrenPlasma transfusionStudy groupHours groupPretransfusion international normalized ratioSolvent/detergent-treated plasmaCritically Ill ChildrenInternational normalized ratioHypothesis-generating dataMultivariable logistic regressionIllness scoresImproved survivalMedian ageAdjusted analysisNormalized ratioPrimary indicationIndependent associationFrozen plasmaObservational studyPlasma useLactate valuesPatients
2016
Massive Transfusion in Children
Karam O, Tucci M. Massive Transfusion in Children. Transfusion Medicine Reviews 2016, 30: 213-216. PMID: 27287298, DOI: 10.1016/j.tmrv.2016.05.010.Peer-Reviewed Original ResearchConceptsMassive transfusionTransfusion protocolTransfusion strategyPacked red blood cellsPediatric trauma patientsGoal-directed therapyWhole bloodMassive transfusion protocolHigh-quality evidenceCritical illnessRed blood cellsTransfusion supportAdjunctive treatmentTrauma patientsQuality evidenceClinical indicatorsTransfusionLaboratory testsBlood componentsBlood cellsFurther studiesAdditional investigationChildrenAdverse consequencesBlood
2013
International survey on plasma transfusion practices in critically ill children
Karam O, Tucci M, Lacroix J, Rimensberger PC, Network C. International survey on plasma transfusion practices in critically ill children. Transfusion 2013, 54: 1125-1132. PMID: 24032693, DOI: 10.1111/trf.12393.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryPediatric critical care physiciansPlasma transfusion practicesInternational normalized ratioCritical care physiciansPlasma transfusionTransfusion practiceCare physiciansRed blood cell transfusion practicesAbnormal international normalized ratioPediatric critical care unitCardiac postoperative patientsTransfusion practice patternsSeptic shock patientsDemographic characteristicsCritical care unitsPartial thromboplastin timeProportion of physiciansFallot correctionNonbleeding patientsMinor bleedingShock patientsTransfusion thresholdPostoperative patientsSeptic shockAssociation between plasma transfusions and clinical outcome in critically ill children: a prospective observational study
Karam O, Lacroix J, Robitaille N, Rimensberger PC, Tucci M. Association between plasma transfusions and clinical outcome in critically ill children: a prospective observational study. Vox Sanguinis 2013, 104: 342-349. PMID: 23294337, DOI: 10.1111/vox.12009.Peer-Reviewed Original ResearchConceptsProgressive multiple organ dysfunction syndromeMultiple organ dysfunction syndromeOrgan dysfunction syndromeIntensive care unit lengthPlasma transfusionDysfunction syndromeClinical outcomesIll childrenNosocomial infectionsCare unitOdds ratioOutcome measuresPediatric intensive care unitPediatric critical care unitProspective pediatric studiesAdult trauma patientsProspective observational studySingle-center studySecondary outcome measuresWorse clinical outcomesExtracorporeal life supportPrimary outcome measureSeverity of illnessIntensive care unitCritical care units