2010
Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients
Gauvin F, Spinella PC, Lacroix J, Choker G, Ducruet T, Karam O, Hébert PC, Hutchison JS, Hume HA, Tucci M, Network O. Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients. Transfusion 2010, 50: 1902-1913. PMID: 20456697, DOI: 10.1111/j.1537-2995.2010.02661.x.Peer-Reviewed Original ResearchConceptsMultiple organ dysfunction syndromeProgressive multiple organ dysfunction syndromeOrgan dysfunction syndromeIll childrenDysfunction syndromePediatric Logistic Organ Dysfunction scoreRed blood cell storage timeLogistic Organ Dysfunction scorePediatric intensive care patientsOrgan dysfunction scoreIntensive care patientsRBC storage timeMultivariate logistic regressionRed blood cellsDysfunction scoreCare patientsRestrictive groupIndependent associationCohort analysisPatientsHigh mortalityGreater riskLogistic regressionRBC unitsStudy design
2009
Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells
Karam O, Tucci M, Toledano BJ, Robitaille N, Cousineau J, Thibault L, Lacroix J, Le Deist F. Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells. Transfusion 2009, 49: 2326-2334. PMID: 19624600, DOI: 10.1111/j.1537-2995.2009.02319.x.Peer-Reviewed Original ResearchConceptsWhole blood culturesT cell activationCD25 expressionBlood culturesLeukoreduced RBCsRBC unitsBlood cellsRed blood cell unitsIL-10 levelsTNF-alpha levelsIL-6 levelsTNF-alpha productionTumor necrosis factorWhite blood cellsRed blood cellsIL-10Blood recipientsCytokine productionIL-6Immunomodulatory effectsCytokine releaseNecrosis factorRBC supernatantsDay 1Day 24