2019
Next-generation Sequencing in the Management of Gastric and Esophageal Cancers
Rubinstein JC, Nicolson NG, Ahuja N. Next-generation Sequencing in the Management of Gastric and Esophageal Cancers. Surgical Clinics Of North America 2019, 99: 511-527. PMID: 31047039, DOI: 10.1016/j.suc.2019.02.005.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaEsophageal NeoplasmsGenomicsHigh-Throughput Nucleotide SequencingHumansMicrosatellite InstabilityMolecular Targeted TherapyStomach NeoplasmsTerminology as TopicConceptsNext-generation sequencingHigh-throughput sequencing technologyAvailable genomic dataSingle-nucleotide resolutionGenome-wide molecular profilingSpecific oncogenic pathwaysSequencing technologiesGenomic dataOncogenic pathwaysGenomic profilesMolecular profilingSequencingPathwayDifficult disease processManagement of gastricIndividual tumorsOrgan-specific treatmentTumorigenesisAbundanceProfilingCancer careEsophageal malignancyEsophageal cancerImmense potentialDisease process
2017
A Four-Gene Promoter Methylation Marker Panel Consisting of GREM1, NEURL, LAD1, and NEFH Predicts Survival of Clear Cell Renal Cell Cancer Patients
van Vlodrop IJH, Joosten SC, De Meyer T, Smits KM, Van Neste L, Melotte V, Baldewijns MMLL, Schouten LJ, van den Brandt PA, Jeschke J, Yi JM, Schuebel KE, Ahuja N, Herman JG, Aarts MJ, Bosman FT, Van Criekinge W, van Engeland M. A Four-Gene Promoter Methylation Marker Panel Consisting of GREM1, NEURL, LAD1, and NEFH Predicts Survival of Clear Cell Renal Cell Cancer Patients. Clinical Cancer Research 2017, 23: 2006-2018. PMID: 27756787, DOI: 10.1158/1078-0432.ccr-16-1236.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAutoantigensBiomarkers, TumorCarcinoma, Renal CellDisease-Free SurvivalDNA MethylationFemaleHigh-Throughput Nucleotide SequencingHumansIntercellular Signaling Peptides and ProteinsKaplan-Meier EstimateKidney NeoplasmsMaleMiddle AgedNeurofilament ProteinsNon-Fibrillar CollagensOligonucleotide Array Sequence AnalysisPrognosisPromoter Regions, GeneticProportional Hazards ModelsUbiquitin-Protein LigasesConceptsClear cell renal cell carcinomaPrognostic modelNonmetastatic clear cell renal cell carcinomaMethylation markersCox proportional hazards modelPrimary clear cell renal cell carcinomaIndependent patient seriesCause-specific survivalOutcomes of patientsCell renal cell carcinomaPrognosis of patientsKaplan-Meier curvesLog-rank testConfidence intervalsCurrent prognostic modelsRenal cell carcinomaProportional hazards modelClin Cancer ResCcRCC cell linesCancer Genome AtlasClinicopathologic featuresPatient seriesCell carcinomaMethylation-specific PCRPoor survival