Diet-induced Lethality Due to Deletion of the Hdac3 Gene in Heart and Skeletal Muscle
Sun Z, Singh N, Mullican SE, Everett LJ, Li L, Yuan L, Liu X, Epstein JA, Lazar MA. Diet-induced Lethality Due to Deletion of the Hdac3 Gene in Heart and Skeletal Muscle. Journal Of Biological Chemistry 2011, 286: 33301-33309. PMID: 21808063, PMCID: PMC3190900, DOI: 10.1074/jbc.m111.277707.Peer-Reviewed Original ResearchConceptsNutritional environmentProper mitochondrial functionHistone deacetylase 3Bioenergetic genesSkeletal muscleNucleosomal histonesHDAC3 geneGene expressionCovalent modificationHuman diseasesHDAC3Mitochondrial functionEmbryonic deletionCardiac mitochondriaGenesLipid metabolismDeletionMilder phenotypePhenotypeMajor cardiomyopathiesLethalityEpigenomeGenomeHistonesMouse model