SDPS-20 THE HER2 FLIP: HER2 AMPLIFICATION OF TUMOR CELLS IN THE CEREBROSPINAL FLUID (CSF-TCS) OF PATIENTS WITH LEPTOMENINGEAL METASTASIS HAVING SOLID TUMORS; IMPLICATIONS FOR TREATING THE LM TUMOR WITH ANTI-HER2 THERAPY
Kumthekar P, Youssef M, Blondin N, Azadi A, Piccioni D, Glantz M, Carillo J, Avgeropoulos N, Makar S, Blouw B, Natasha A, Fisher D, Huynh L, Peters J, Sweed N, Dugan M, Kesari S. SDPS-20 THE HER2 FLIP: HER2 AMPLIFICATION OF TUMOR CELLS IN THE CEREBROSPINAL FLUID (CSF-TCS) OF PATIENTS WITH LEPTOMENINGEAL METASTASIS HAVING SOLID TUMORS; IMPLICATIONS FOR TREATING THE LM TUMOR WITH ANTI-HER2 THERAPY. Neuro-Oncology Advances 2023, 5: iii20-iii20. PMCID: PMC10402348, DOI: 10.1093/noajnl/vdad070.077.Peer-Reviewed Original ResearchNon-small cell lung cancerUpper GI cancerHER2-negative primary tumorsAnti-HER2 therapyBreast cancer patientsLeptomeningeal metastasesNegative primary tumorsPrimary tumorHER2 amplificationGI cancersCancer patientsNSCLC patientsBreast cancerHER2-positive primary tumorsUpper GI cancer patientsCSF tumor cellsGI cancer patientsPositive primary tumorsCell lung cancerDiscretion of physiciansIT trastuzumabLM tumorsHER2 positivityNSCLC cancerLM patients