Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo
Gogia N, Sarkar A, Mehta A, Ramesh N, Deshpande P, Kango-Singh M, Pandey UB, Singh A. Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo. Neurobiology Of Disease 2020, 140: 104837. PMID: 32199908, PMCID: PMC9277911, DOI: 10.1016/j.nbd.2020.104837.Peer-Reviewed Original ResearchMeSH KeywordsAmyotrophic Lateral SclerosisAnimalsAxonsCytoplasmDisease Models, AnimalDrosophilaDrosophila ProteinsIntracellular Signaling Peptides and ProteinsMAP Kinase Kinase 4Motor NeuronsMutationNerve DegenerationNeuromuscular JunctionPhenotypeProtein Serine-Threonine KinasesProtein TransportRNA-Binding Protein FUSSignal TransductionConceptsDrosophila eyeHippo signalingJNK signalingAmyotrophic lateral sclerosisCell deathC-Jun amino-terminal kinaseGenetic modifiersInactivation of HippoCJun N-terminal kinaseTrigger cell deathAmino-terminal kinaseGrowth regulatory pathwaysLate-onset neurodegenerative disorderTargeted misexpressionRNA metabolismPromotes Cell ProliferationHippo pathwayInteresting phenotypesDrosophila modelGenetic mechanismsHuman FUSFUS accumulationRegulatory pathwaysAxonal targetingCytoplasmic mislocalization