Featured Publications
Unbiased automated quantitation of ROS signals in live retinal neurons of Drosophila using Fiji/ImageJ
Deshpande P, Gogia N, Chimata AV, Singh A. Unbiased automated quantitation of ROS signals in live retinal neurons of Drosophila using Fiji/ImageJ. BioTechniques 2021, 71: 416-424. PMID: 34350780, PMCID: PMC10288391, DOI: 10.2144/btn-2021-0006.Peer-Reviewed Original ResearchInactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo
Gogia N, Sarkar A, Mehta A, Ramesh N, Deshpande P, Kango-Singh M, Pandey UB, Singh A. Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo. Neurobiology Of Disease 2020, 140: 104837. PMID: 32199908, PMCID: PMC9277911, DOI: 10.1016/j.nbd.2020.104837.Peer-Reviewed Original ResearchMeSH KeywordsAmyotrophic Lateral SclerosisAnimalsAxonsCytoplasmDisease Models, AnimalDrosophilaDrosophila ProteinsIntracellular Signaling Peptides and ProteinsMAP Kinase Kinase 4Motor NeuronsMutationNerve DegenerationNeuromuscular JunctionPhenotypeProtein Serine-Threonine KinasesProtein TransportRNA-Binding Protein FUSSignal TransductionConceptsDrosophila eyeHippo signalingJNK signalingAmyotrophic lateral sclerosisCell deathC-Jun amino-terminal kinaseGenetic modifiersInactivation of HippoCJun N-terminal kinaseTrigger cell deathAmino-terminal kinaseGrowth regulatory pathwaysLate-onset neurodegenerative disorderTargeted misexpressionRNA metabolismPromotes Cell ProliferationHippo pathwayInteresting phenotypesDrosophila modelGenetic mechanismsHuman FUSFUS accumulationRegulatory pathwaysAxonal targetingCytoplasmic mislocalizationProximal fate marker homothorax marks the lateral extension of stalk‐eyed fly Cyrtodopsis whitei
Singh A, Gogia N, Chang C, Sun YH. Proximal fate marker homothorax marks the lateral extension of stalk‐eyed fly Cyrtodopsis whitei. Genesis 2019, 57: e23309. PMID: 31162816, PMCID: PMC6744308, DOI: 10.1002/dvg.23309.Peer-Reviewed Original ResearchConceptsStalk-eyed fliesImaginal discsEye-antennal imaginal discCompound eyeEye imaginal discImportant evolutionary traitAdult compound eyesProximo-distal axisProximal fateEvolutionary traitsSpecific fatesDiptera orderExpression evolvesFamily DiopsidaeInsect headHth expressionDistal fatesAntennal segmentsFliesHomothoraxInsectsAdult eyesWhiteiFatePhenotype
2024
Genetic mechanism regulating diversity in the placement of eyes on the head of animals
Puli O, Gogia N, Chimata A, Yorimitsu T, Nakagoshi H, Kango-Singh M, Singh A. Genetic mechanism regulating diversity in the placement of eyes on the head of animals. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2316244121. PMID: 38588419, PMCID: PMC11032433, DOI: 10.1073/pnas.2316244121.Peer-Reviewed Original ResearchConceptsMorphogen gradientsCell fateRegulate Wg signalingEye developmentGradients of signaling moleculesHomeodomain transcription factorRetinal determination genesWg signalingWnt/Wg signalingGain-of-functionWg expressionEye fateDefective proventriculusDetermination genesEye genesGenetic machineryTranscription factorsRetinal cell fateDevelopmental defectsPatterning cuesMorphogenGenesHead vertexFacial anomaliesFate