A soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eye
Sarkar A, Gogia N, Glenn N, Singh A, Jones G, Powers N, Srivastava A, Kango-Singh M, Singh A. A soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eye. Scientific Reports 2018, 8: 13545. PMID: 30202077, PMCID: PMC6131139, DOI: 10.1038/s41598-018-31787-7.Peer-Reviewed Original ResearchConceptsRetinal neuronsNeuroprotective roleAlzheimer's diseaseHuman Aβ42Fatal progressive neurodegenerative disorderNovel neuroprotective roleProgressive neurodegenerative disorderAnti-cancer effectsPotential therapeutic agentJNK signalingAβ42 plaquesNeuronal deathNeuroprotective functionMortality rateTransgenic modelAxonal targetingNeurodegenerative disordersTherapeutic agentsCJun N-terminal kinaseNeurodegenerationOxidative stressAβ42NeuronsAbnormal signalingLunasinCharacterization of a morphogenetic furrow specific Gal4 driver in the developing Drosophila eye
Sarkar A, Gogia N, Farley K, Payton L, Singh A. Characterization of a morphogenetic furrow specific Gal4 driver in the developing Drosophila eye. PLOS ONE 2018, 13: e0196365. PMID: 29702674, PMCID: PMC5922546, DOI: 10.1371/journal.pone.0196365.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedBody PatterningCell DifferentiationDrosophila melanogasterDrosophila ProteinsGene Expression ProfilingGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsImmunohistochemistryIntracellular Signaling Peptides and ProteinsNuclear ProteinsPhenotypeProtein Serine-Threonine KinasesRetinaRetinal NeuronsTrans-ActivatorsTranscription FactorsTransforming Growth Factor betaWnt1 ProteinYAP-Signaling Proteins