Drosophila Eye Model to Study Neuroprotective Role of CREB Binding Protein (CBP) in Alzheimer’s Disease
Cutler T, Sarkar A, Moran M, Steffensmeier A, Puli OR, Mancini G, Tare M, Gogia N, Singh A. Drosophila Eye Model to Study Neuroprotective Role of CREB Binding Protein (CBP) in Alzheimer’s Disease. PLOS ONE 2015, 10: e0137691. PMID: 26367392, PMCID: PMC4569556, DOI: 10.1371/journal.pone.0137691.Peer-Reviewed Original ResearchConceptsCREB Binding ProteinTargeted misexpressionCBP proteinGAL4/UAS systemBinding proteinGenetic modifiersDrosophila eye modelNormal cellular processesTargeting of axonsFruit fly modelStructure-function analysisAmyloid precursor proteinProgressive neurodegenerative phenotypeTransgenic fliesCellular processesPolyglutamine domainHistone acetylaseNeuroprotective functionPhotoreceptor neuronsFly modelGenetic basisUAS systemAmyloid plaquesMisexpressionDifferent proteins