A Positive Feedback Loop of Hippo- and c-Jun-Amino-Terminal Kinase Signaling Pathways Regulates Amyloid-Beta-Mediated Neurodegeneration
Irwin M, Tare M, Singh A, Puli OR, Gogia N, Riccetti M, Deshpande P, Kango-Singh M, Singh A. A Positive Feedback Loop of Hippo- and c-Jun-Amino-Terminal Kinase Signaling Pathways Regulates Amyloid-Beta-Mediated Neurodegeneration. Frontiers In Cell And Developmental Biology 2020, 8: 117. PMID: 32232042, PMCID: PMC7082232, DOI: 10.3389/fcell.2020.00117.Peer-Reviewed Original ResearchHippo signalingJNK signalingCell deathKinase Signaling PathwayTriggers cell proliferationActivation of HippoDeficiency screenTargeted misexpressionNeurodegeneration phenotypePositive feedback loopAge-related disordersTerminal kinaseSignaling pathwaysAberrant signalingAccumulation of Aβ42HippoNovel roleNeurodegenerative phenotypeGenetic modifiersHuman Aβ42SignalingCell proliferationDeath of neuronsAβ42 plaquesPathwayA soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eye
Sarkar A, Gogia N, Glenn N, Singh A, Jones G, Powers N, Srivastava A, Kango-Singh M, Singh A. A soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eye. Scientific Reports 2018, 8: 13545. PMID: 30202077, PMCID: PMC6131139, DOI: 10.1038/s41598-018-31787-7.Peer-Reviewed Original ResearchConceptsRetinal neuronsNeuroprotective roleAlzheimer's diseaseHuman Aβ42Fatal progressive neurodegenerative disorderNovel neuroprotective roleProgressive neurodegenerative disorderAnti-cancer effectsPotential therapeutic agentJNK signalingAβ42 plaquesNeuronal deathNeuroprotective functionMortality rateTransgenic modelAxonal targetingNeurodegenerative disordersTherapeutic agentsCJun N-terminal kinaseNeurodegenerationOxidative stressAβ42NeuronsAbnormal signalingLunasin