Ahsg-fetuin blocks the metabolic arm of insulin action through its interaction with the 95-kD β-subunit of the insulin receptor
Goustin A, Derar N, Abou-Samra A. Ahsg-fetuin blocks the metabolic arm of insulin action through its interaction with the 95-kD β-subunit of the insulin receptor. Cellular Signalling 2013, 25: 981-988. PMID: 23314177, DOI: 10.1016/j.cellsig.2012.12.011.Peer-Reviewed Original ResearchConceptsB subunitInsulin-stimulated GLUT4 translocationHigh-affinity binding of insulinLevel of tyrosine phosphorylationA subunitInsulin receptorTyrosine kinaseInhibiting insulin receptorTreatment of myogenic cellsFurin processing siteSignal peptideGLUT4 translocationHigh-affinity bindingTyrosine phosphorylationATP-dependent systemHEK293 transfected cellsBinding of insulinInsulin signalingProcessing siteTransfected cellsIntact cellsAkt activationAkt phosphorylationLiving cellsHEK293 cells