2010
Testing Predictions From Personality Neuroscience
DeYoung CG, Hirsh JB, Shane MS, Papademetris X, Rajeevan N, Gray JR. Testing Predictions From Personality Neuroscience. Psychological Science 2010, 21: 820-828. PMID: 20435951, PMCID: PMC3049165, DOI: 10.1177/0956797610370159.Peer-Reviewed Original ResearchConceptsPersonality neuroscienceBrain regionsLateral prefrontal cortexMedial orbitofrontal cortexBig Five personalityStructural magnetic resonance imagingNegative affectReward informationMental statesOrbitofrontal cortexPrefrontal cortexBig FiveDifferent brain regionsVoluntary controlExplanatory modelsWhole brain volumeConscientiousnessNeuroscienceExtraversionAgreeablenessNeuroticismHealthy adultsBiological basisCortexMagnetic resonance imaging
2009
Functional connectivity and alterations in baseline brain state in humans
Martuzzi R, Ramani R, Qiu M, Rajeevan N, Constable RT. Functional connectivity and alterations in baseline brain state in humans. NeuroImage 2009, 49: 823-834. PMID: 19631277, PMCID: PMC2764802, DOI: 10.1016/j.neuroimage.2009.07.028.Peer-Reviewed Original ResearchConceptsDefault mode networkMAC sevoflurane anesthesiaBaseline brain activityFunctional connectivity fMRISevoflurane anesthesiaHigher-order brain regionsAnesthetized conditionSensory cortexDifferent brain networksBaseline activityBrain regionsHuman volunteersSensory areasFunctional connectivityAnesthesiaMode networkLow-level sensory areasBrain networksBrain activityCognitive regionsBrain propertiesBrain statesFurther evidencePainThalamusAlterations in neural connectivity in preterm children at school age
Gozzo Y, Vohr B, Lacadie C, Hampson M, Katz KH, Maller-Kesselman J, Schneider KC, Peterson BS, Rajeevan N, Makuch RW, Constable RT, Ment LR. Alterations in neural connectivity in preterm children at school age. NeuroImage 2009, 48: 458-463. PMID: 19560547, PMCID: PMC2775072, DOI: 10.1016/j.neuroimage.2009.06.046.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingLanguage tasksWernicke's areaLanguage processingPeabody Individual Achievement TestRight inferior frontal gyrusPT childrenAuditory language functionsAuditory language taskCortical language regionsSchool ageInferior frontal gyrusReading comprehension testWechsler Intelligence ScalePeabody Picture VocabularyInferior parietal lobulePT subjectsSchool-aged childrenChildren-IIIComprehension testFrontal gyrusIntelligence ScalePicture VocabularyWISC-IIILanguage regions
2008
Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjects
Qiu M, Ramani R, Swetye M, Rajeevan N, Constable RT. Anesthetic effects on regional CBF, BOLD, and the coupling between task‐induced changes in CBF and BOLD: An fMRI study in normal human subjects. Magnetic Resonance In Medicine 2008, 60: 987-996. PMID: 18816821, PMCID: PMC2716171, DOI: 10.1002/mrm.21759.Peer-Reviewed Original ResearchConceptsCerebral blood flowLow-dose sevofluraneRegional cerebral blood flowTask-induced changesBaseline cerebral blood flowBlood oxygen level-dependent (BOLD) signalAbsence of anesthesiaHealthy human subjectsHuman subjectsNormal human subjectsLevel-dependent signalFunctional MR imagingVascular measuresAnesthetic agentsBlood flowAnesthetic effectSevofluraneFunctional MRI dataAnesthesia conditionsAnesthesiaMR imagingAuditory regionsOxidative metabolismAuditory stimuliFMRI study
2000
Test-retest reproducibility of extrastriatal dopamine D2 receptor imaging with [123I]epidepride SPECT in humans.
Varrone A, Fujita M, Verhoeff NP, Zoghbi SS, Baldwin RM, Rajeevan N, Charney DS, Seibyl JP, Innis RB. Test-retest reproducibility of extrastriatal dopamine D2 receptor imaging with [123I]epidepride SPECT in humans. Journal Of Nuclear Medicine 2000, 41: 1343-51. PMID: 10945525.Peer-Reviewed Original ResearchConceptsTest-retest variabilityTemporal cortexTest-retest reproducibilityOutcome measuresExtrastriatal regionsD2 receptorsPlasma clearanceExtrastriatal dopamine D2 receptorsGood test-retest variabilityConstant infusion paradigmExtrastriatal D2 receptorsDopamine D2 receptorsBrain radioactivityStriatal radioactivityHealthy volunteersReceptor densityInfusion rateParent tracerSPECT studiesLess test-retest variabilityCortexHigh test-retest variabilityFree fractionReceptor quantificationReceptors
1999
Graphical analysis and simplified quantification of striatal and extrastriatal dopamine D2 receptor binding with [123I]epidepride SPECT.
Ichise M, Fujita M, Seibyl JP, Verhoeff NP, Baldwin RM, Zoghbi SS, Rajeevan N, Charney DS, Innis RB. Graphical analysis and simplified quantification of striatal and extrastriatal dopamine D2 receptor binding with [123I]epidepride SPECT. Journal Of Nuclear Medicine 1999, 40: 1902-12. PMID: 10565788.Peer-Reviewed Original ResearchConceptsSignificant intersubject variabilityD2 receptorsBlood dataDistribution volumeExtrastriatal dopamine D2 receptorsIntersubject variabilityExtrastriatal D2 receptorsDopamine D2 receptorsSingle blood samplingReceptor-containing regionsNondisplaceable compartmentNondisplaceable distribution volumeHealthy volunteersBlood samplingD2 bindingSPECT studiesTissue ratioPlasma samplesPresence of metabolitesMultilinear regression analysisRegression analysisStriatalReceptorsMetabolite activityLipophilic metabolites[123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia
Verhoeff N, Soares J, D’Souza C, Gil R, Degen K, Abi-Dargham A, Zoghbi S, Fujita M, Rajeevan N, Seibyl J, Krystal J, van Dyck C, Charney D, Innis R. [123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia. Psychiatry Research 1999, 91: 163-173. PMID: 10641580, DOI: 10.1016/s0925-4927(99)00027-x.Peer-Reviewed Original ResearchConceptsDuration of illnessHealthy control subjectsControl subjectsGamma-aminobutyric acidLeft precentral gyrusSuperior occipital gyrusPANSS scoresPrecentral gyrusOccipital gyrusSignificant differencesTotal brain uptakeNon-smoking patientsGray matter atrophyConstant infusion paradigmPathophysiology of schizophreniaCortical brain regionsSingle photon emissionTypical antipsychoticsAtypical antipsychoticsCigarette smokingInhibitory neurotransmissionBrain uptakeInfusion paradigmMatter atrophyPostmortem studies
1998
Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and 123IIomazenil
Abi-Dargham A, Krystal JH, Anjilvel S, Scanley BE, Zoghbi S, Baldwin RM, Rajeevan N, Ellis S, Petrakis IL, Seibyl JP, Charney DS, Laruelle M, Innis RB. Alterations of Benzodiazepine Receptors in Type II Alcoholic Subjects Measured With SPECT and 123IIomazenil. American Journal Of Psychiatry 1998, 155: 1550-1555. PMID: 9812116, DOI: 10.1176/ajp.155.11.1550.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsBenzodiazepine receptorsComparison subjectsAlcoholic subjectsDistribution volumeAlcoholic patientsAnterior cingulateBenzodiazepine receptor densityRight middle frontal gyrusLeft occipital cortexType II alcoholismSingle photon emissionMiddle frontal gyrusStatistical parametric mappingContinuous infusionReceptor radiotracerReceptor densityOccipital cortexCerebellar cortexCortical regionsPatientsFrontal gyrusInterest analysisVivo studiesParametric mappingSignificance of nonuniform attenuation correction in quantitative brain SPECT imaging.
Rajeevan N, Zubal IG, Ramsby SQ, Zoghbi SS, Seibyl J, Innis RB. Significance of nonuniform attenuation correction in quantitative brain SPECT imaging. Journal Of Nuclear Medicine 1998, 39: 1719-26. PMID: 9776276.Peer-Reviewed Original ResearchConceptsHealthy control subjectsHealthy human control subjectsHuman control subjectsControl subjectsDisease patientsGroup of patientsParkinson's disease patientsNonuniform attenuation correctionOutcome measuresParkinson's diseaseSPECT scansBrain SPECTBrain regionsDopamine transporterPatientsBackground activity ratioNonuniform attenuation mapGold standardModerate improvementScansBrain ROIsSPECT imagesAttenuation correctionDiseaseQuantitative brain SPECT