2020
Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans
Bigdeli TB, Fanous AH, Li Y, Rajeevan N, Sayward F, Genovese G, Gupta R, Radhakrishnan K, Malhotra AK, Sun N, Lu Q, Hu Y, Li B, Chen Q, Mane S, Miller P, Cheung KH, Gur RE, Greenwood TA, Braff DL, on the Genetics of Schizophrenia C, Achtyes ED, Buckley PF, Escamilla MA, Lehrer D, Malaspina DP, McCarroll SA, Rapaport MH, Vawter P, Pato MT, Pato CN, Investigators G, Zhao H, Kosten TR, Brophy M, Pyarajan S, Shi Y, O’Leary T, Gleason T, Przygodzki R, Muralidhar S, Gaziano JM, Program M, Huang GD, Concato J, Siever LJ, Aslan M, Harvey PD. Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans. Schizophrenia Bulletin 2020, 47: 517-529. PMID: 33169155, PMCID: PMC7965063, DOI: 10.1093/schbul/sbaa133.Peer-Reviewed Original Research
2019
Genome‐wide association study of cognitive performance in U.S. veterans with schizophrenia or bipolar disorder
Harvey PD, Sun N, Bigdeli TB, Fanous AH, Aslan M, Malhotra AK, Lu Q, Hu Y, Li B, Chen Q, Mane S, Miller P, Rajeevan N, Sayward F, Cheung K, Li Y, Greenwood TA, Gur RE, Braff DL, on the Genetics of Schizophrenia C, Brophy M, Pyarajan S, O'Leary TJ, Gleason T, Przygodszki R, Muralidhar S, Gaziano JM, Concato J, Zhao H, Siever LJ. Genome‐wide association study of cognitive performance in U.S. veterans with schizophrenia or bipolar disorder. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2019, 183: 181-194. PMID: 31872970, DOI: 10.1002/ajmg.b.32775.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAllelesBipolar DisorderCognitionCognition DisordersFemaleGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedNeuropsychological TestsOligonucleotide Array Sequence AnalysisPolymorphism, Single NucleotideSchizophreniaUnited StatesUnited States Department of Veterans AffairsVeterans
2018
Suicidal ideation and behavior in US veterans with schizophrenia or bipolar disorder
Harvey PD, Posner K, Rajeevan N, Yershova KV, Aslan M, Concato J. Suicidal ideation and behavior in US veterans with schizophrenia or bipolar disorder. Journal Of Psychiatric Research 2018, 102: 216-222. PMID: 29698922, DOI: 10.1016/j.jpsychires.2018.04.014.Peer-Reviewed Original ResearchConceptsSevere mental illnessSuicidal ideationPsychiatric comorbidityUS veteransHigh riskVeteran populationGreater clinical focusPopulation of patientsVeterans Affairs studyMultiple psychiatric comorbiditiesStudy of veteransLifetime suicidal ideationHigh suicide riskDemographic factorsBetter risk predictionMajority of veteransClinical factorsFunctional statusLifetime riskRisk factorsMajor depressionMultinomial logistic regressionLower riskSCZ patientsClinical attributes
2016
Impact of genotyping errors on statistical power of association tests in genomic analyses: A case study
Hou L, Sun N, Mane S, Sayward F, Rajeevan N, Cheung K, Cho K, Pyarajan S, Aslan M, Miller P, Harvey PD, Gaziano JM, Concato J, Zhao H. Impact of genotyping errors on statistical power of association tests in genomic analyses: A case study. Genetic Epidemiology 2016, 41: 152-162. PMID: 28019059, PMCID: PMC5604789, DOI: 10.1002/gepi.22027.Peer-Reviewed Original Research
1999
[123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia
Verhoeff N, Soares J, D’Souza C, Gil R, Degen K, Abi-Dargham A, Zoghbi S, Fujita M, Rajeevan N, Seibyl J, Krystal J, van Dyck C, Charney D, Innis R. [123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia. Psychiatry Research 1999, 91: 163-173. PMID: 10641580, DOI: 10.1016/s0925-4927(99)00027-x.Peer-Reviewed Original ResearchConceptsDuration of illnessHealthy control subjectsControl subjectsGamma-aminobutyric acidLeft precentral gyrusSuperior occipital gyrusPANSS scoresPrecentral gyrusOccipital gyrusSignificant differencesTotal brain uptakeNon-smoking patientsGray matter atrophyConstant infusion paradigmPathophysiology of schizophreniaCortical brain regionsSingle photon emissionTypical antipsychoticsAtypical antipsychoticsCigarette smokingInhibitory neurotransmissionBrain uptakeInfusion paradigmMatter atrophyPostmortem studies