2022
The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract
Zhou Y, Gu B, Brichant G, Singh JP, Yang H, Chang H, Zhao Y, Cheng C, Liu ZW, Alderman MH, Lu L, Yang X, Gao XB, Taylor HS. The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract. BMC Biology 2022, 20: 93. PMID: 35491423, PMCID: PMC9059368, DOI: 10.1186/s12915-022-01293-4.Peer-Reviewed Original ResearchConceptsEstrogen receptorMaintenance of pregnancyFetal mouse brainReproductive systemE3 micePregnancy outcomesEstrogen actionEstrogen potencyPregnant miceEstrogen exposureEstrogen signalingFetal developmentMouse brainSteroid hormonesUnexpected functional rolesPregnancyReproductive tractHormone estriolBrainReceptorsExpression levelsFetusesExploratory behaviorMiceNovel mechanism
2020
Fetal Bisphenol-A Induced Changes in Murine Behavior and Brain Gene Expression Persisted in Adult-aged Offspring
Wang Z, Alderman MH, Asgari C, Taylor HS. Fetal Bisphenol-A Induced Changes in Murine Behavior and Brain Gene Expression Persisted in Adult-aged Offspring. Endocrinology 2020, 161: bqaa164. PMID: 32926169, PMCID: PMC7609133, DOI: 10.1210/endocr/bqaa164.Peer-Reviewed Original ResearchConceptsUtero exposureLocomotor activityUtero bisphenol A (BPA) exposureBisphenol A (BPA) exposureSignificant decreaseAnxiety-like behaviorDeclarative memory impairmentSex-specific mannerA ExposureFemale miceMale miceBPA exposureRelevant doseMotor coordinationMouse modelMurine behaviourControl animalsNeurobehavioral functionBPA treatmentLocomotor deficitsMemory impairmentOlder ageBrain developmentLong-term memoryBrain gene expression