2020
Fetal Bisphenol-A Induced Changes in Murine Behavior and Brain Gene Expression Persisted in Adult-aged Offspring
Wang Z, Alderman MH, Asgari C, Taylor HS. Fetal Bisphenol-A Induced Changes in Murine Behavior and Brain Gene Expression Persisted in Adult-aged Offspring. Endocrinology 2020, 161: bqaa164. PMID: 32926169, PMCID: PMC7609133, DOI: 10.1210/endocr/bqaa164.Peer-Reviewed Original ResearchConceptsUtero exposureLocomotor activityUtero bisphenol A (BPA) exposureBisphenol A (BPA) exposureSignificant decreaseAnxiety-like behaviorDeclarative memory impairmentSex-specific mannerA ExposureFemale miceMale miceBPA exposureRelevant doseMotor coordinationMouse modelMurine behaviourControl animalsNeurobehavioral functionBPA treatmentLocomotor deficitsMemory impairmentOlder ageBrain developmentLong-term memoryBrain gene expression
2016
Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol‐A) exposure
Jorgensen EM, Alderman MH, Taylor HS. Preferential epigenetic programming of estrogen response after in utero xenoestrogen (bisphenol‐A) exposure. The FASEB Journal 2016, 30: 3194-3201. PMID: 27312807, PMCID: PMC5001514, DOI: 10.1096/fj.201500089r.Peer-Reviewed Original ResearchConceptsEstrogen responseSubsequent gene expressionGene expressionXenoestrogen exposureBPA exposureEpigenetic programmingUtero BPA exposurePrenatal BPA exposureRisk of estrogenMajority of genesNormal developmental programmingFemale reproductive disordersCpG methylation patternsCpG methylation profilesEstrogen-responsive gene expressionUterine DNAEstrogen-responsive genesEndometrial hyperplasiaUtero exposurePregnant miceEtiological factorsBreast cancerEstrogen receptorMethylation patternsRelevant dose