2014
Unfolded protein response prevents blastocyst formation during preimplantation embryo development in vitro
Basar M, Bozkurt I, Guzeloglu-Kayisli O, Sozen B, Tekmen I, Schatz F, Arici A, Lockwood CJ, Kayisli UA. Unfolded protein response prevents blastocyst formation during preimplantation embryo development in vitro. Fertility And Sterility 2014, 102: 1777-1784. PMID: 25305729, DOI: 10.1016/j.fertnstert.2014.09.004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBlastocystEmbryo Culture TechniquesEmbryonic DevelopmentEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressGonadotropins, EquineHeat-Shock ProteinsMiceUnfolded Protein ResponseConceptsUnfolded protein responseProtein responseBlastocyst formationEmbryo developmentActivation of UPRPreimplantation embryo developmentTM treatmentBlastocyst developmentEffect of tunicamycinEndoplasmic reticulum stressEmbryonic developmentER stressCell embryosNuclear fragmentationMorphological differencesImmunoglobulin proteinBlastocyst stageReticulum stressTunicamycinDevelopment ratePregnant mare serum gonadotropinBlastocyst development rateProtein-1 mRNA expressionNongenomic mechanismsEmbryos
2011
Bidirectional Interaction Between Unfolded-Protein-Response Key Protein HSPA5 and Estrogen Signaling in Human Endometrium1
Guzel E, Basar M, Ocak N, Arici A, Kayisli UA. Bidirectional Interaction Between Unfolded-Protein-Response Key Protein HSPA5 and Estrogen Signaling in Human Endometrium1. Biology Of Reproduction 2011, 85: 121-127. PMID: 21389343, DOI: 10.1095/biolreprod.110.089532.Peer-Reviewed Original ResearchConceptsHSPA5 expressionHuman endometriumMenstrual cycleStromal cellsUnfolded protein responseNormal human endometriumEndometrial glandularEstradiol levelsHuman Endometrium1Possible inverse correlationIshikawa cellsEstrogen signalingLocal paracrineEndometriumSteroid hormonesAutocrine factorHeat shock 70EstrogenInverse correlationBidirectional regulationExpression levelsBidirectional interactionsShock 70Dynamic tissueHSPA5