2019
Assessing the interactions between radiotherapy and antitumour immunity
Grassberger C, Ellsworth S, Wilks M, Keane F, Loeffler J. Assessing the interactions between radiotherapy and antitumour immunity. Nature Reviews Clinical Oncology 2019, 16: 729-745. PMID: 31243334, DOI: 10.1038/s41571-019-0238-9.Peer-Reviewed Original ResearchMeSH KeywordsCombined Modality TherapyHumansImmune SystemImmunotherapyNeoplasmsPrecision MedicineRadiotherapyConceptsImmune checkpoint inhibitorsCheckpoint inhibitorsIntroduction of immune checkpoint inhibitorsTherapy-induced immune responsesLong-term tumor controlImmune responsePre-existing immune responsesImmune response to radiotherapyInteraction of immunotherapyResponse to radiotherapyAdvanced-stage diseaseRadiation-induced immunosuppressionImmune cell dynamicsSite of diseaseIndividualized treatment approachPatient levelAntitumour immunityRadiotherapy regimensTumor controlTreatment of cancerIncrease response ratesRadiotherapyImmunotherapySerum biomarkersClinical data
2015
Imaging PEG-Like Nanoprobes in Tumor, Transient Ischemia, and Inflammatory Disease Models
Wilks M, Normandin M, Yuan H, Cho H, Guo Y, Herisson F, Ayata C, Wooten D, Fakhri G, Josephson L. Imaging PEG-Like Nanoprobes in Tumor, Transient Ischemia, and Inflammatory Disease Models. Bioconjugate Chemistry 2015, 26: 1061-1069. PMID: 25971846, PMCID: PMC5378316, DOI: 10.1021/acs.bioconjchem.5b00213.Peer-Reviewed Original Research
2013
An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Williams K, Argus J, Zhu Y, Wilks M, Marbois B, York A, Kidani Y, Pourzia A, Akhavan D, Lisiero D, Komisopoulou E, Henkin A, Soto H, Chamberlain B, Vergnes L, Jung M, Torres J, Liau L, Christofk H, Prins R, Mischel P, Reue K, Graeber T, Bensinger S. An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity. Cancer Research 2013, 73: 2850-2862. PMID: 23440422, PMCID: PMC3919498, DOI: 10.1158/0008-5472.can-13-0382-t.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CycleCell Line, TumorCell ProliferationFatty Acid SynthasesGene Expression ProfilingGene Expression Regulation, NeoplasticHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceMice, Inbred NODModels, StatisticalNeoplasm TransplantationNeoplasmsSignal TransductionStearoyl-CoA DesaturaseSterolsConceptsSterol regulatory element-binding proteinsFatty acid synthesisSREBP activityCellular growthFatty acid poolKey transcriptional regulatorCancer cellsFatty acid desaturationAcid synthesisAcid poolElement-binding proteinMetabolic flux analysisTranscriptional regulatorsLipid biosynthesisNovel mechanistic explanationStearoyl-CoA desaturase-1Fatty acid synthase activityCancer metabolismCancer cell growthSignaling AxisCell growthFlux analysisSynthase activityDesaturase 1Lipid profiling