Location-Dependent Excitatory Synaptic Interactions in Pyramidal Neuron Dendrites
Behabadi BF, Polsky A, Jadi M, Schiller J, Mel BW. Location-Dependent Excitatory Synaptic Interactions in Pyramidal Neuron Dendrites. PLOS Computational Biology 2012, 8: e1002599. PMID: 22829759, PMCID: PMC3400572, DOI: 10.1371/journal.pcbi.1002599.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsDendritesExcitatory Postsynaptic PotentialsModels, NeurologicalN-MethylaspartateNeural ConductionPatch-Clamp TechniquesPyramidal CellsRatsRats, WistarSynapsesConceptsExcitatory synaptic contactsPyramidal neuronsSynaptic contactsSpike thresholdExcitatory synaptic interactionsBasal dendritic arborsNeocortical pyramidal neuronsMore proximal inputsBasal dendritesExcitatory pathwaysDendritic arborsDistal excitationBrain slicesSynaptic projectionsSynaptic interactionsElectrophysiological recordingsProximal inputsResponse modulationFunctional asymmetryNeuronsPeak responseSomaDistal endPN responsesDendritesLocation-Dependent Effects of Inhibition on Local Spiking in Pyramidal Neuron Dendrites
Jadi M, Polsky A, Schiller J, Mel BW. Location-Dependent Effects of Inhibition on Local Spiking in Pyramidal Neuron Dendrites. PLOS Computational Biology 2012, 8: e1002550. PMID: 22719240, PMCID: PMC3375251, DOI: 10.1371/journal.pcbi.1002550.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAlpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsCalcium SignalingComputational BiologyComputer SimulationDendritesExcitatory Postsynaptic PotentialsGamma-Aminobutyric AcidIn Vitro TechniquesMaleModels, NeurologicalN-MethylaspartatePyramidal CellsRatsRats, WistarSomatosensory CortexConceptsPyramidal neuronsDendritic inhibitionInterneuron typesDendritic spikesLayer 5 pyramidal neuronsSpike thresholdDistal dendritic inhibitionInhibitory interneuron typesSpike initiation zoneDendritic spike thresholdDifferent neural pathwaysBasal dendritesSynaptic contactsNeocortical slicesCortical circuitsDendritic responsesNeural pathwaysSomatic inhibitionLocal spikingSpike generationCortical computationRelative activationInhibitionDetailed compartmental modelNeurons