Myometrial‐derived CXCL12 promotes lipopolysaccharide induced preterm labour by regulating macrophage migration, polarization and function in mice
Zhang L, Mamillapalli R, Habata S, McAdow M, Taylor HS. Myometrial‐derived CXCL12 promotes lipopolysaccharide induced preterm labour by regulating macrophage migration, polarization and function in mice. Journal Of Cellular And Molecular Medicine 2022, 26: 2566-2578. PMID: 35318804, PMCID: PMC9077289, DOI: 10.1111/jcmm.17252.Peer-Reviewed Original ResearchConceptsInflammation-related cytokinesSmooth muscle cellsPreterm laborCXCL12/CXCR4Preterm birthMacrophage migrationIL-6M1 polarizationPregnant miceImmune cellsCXCL12/CXCR4 axisTreatment of SMCsTumor necrosis factor alphaInduced preterm laborInfiltration of neutrophilsMacrophage M1 polarizationStart of labourNecrosis factor alphaTNF-α expressionPrimary smooth muscle cellsPremature laborPregnancy durationGestational tissuesMacrophage infiltrationNeonatal mortality