2016
Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing
Thomer L, Emolo C, Thammavongsa V, Kim H, McAdow M, Yu W, Kieffer M, Schneewind O, Missiakas D. Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing. Journal Of Experimental Medicine 2016, 213: 293-301. PMID: 26880578, PMCID: PMC4813671, DOI: 10.1084/jem.20150074.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusBloodstream infectionsPhagocytic killingElicit cross-protective immune responsesCross-protective immune responsesProtective fibrin shieldS. aureus vaccineAureus vaccineClinical efficacyMRSA isolatesImmune cellsOpsonophagocytic killingFrequent causeImmune responseHost immunityHost prothrombinProtective antigenSpecific antibodiesInfectionSurface moleculesAntibodiesS. aureusStaphylococcus aureusAntibody therapeuticsStaphylococcal surface
2012
Coagulases as Determinants of Protective Immune Responses against Staphylococcus aureus
McAdow M, DeDent AC, Emolo C, Cheng AG, Kreiswirth BN, Missiakas DM, Schneewind O. Coagulases as Determinants of Protective Immune Responses against Staphylococcus aureus. Infection And Immunity 2012, 80: 3389-3398. PMID: 22825443, PMCID: PMC3457572, DOI: 10.1128/iai.00562-12.Peer-Reviewed Original ResearchStaphylococcus aureus Secretes Coagulase and von Willebrand Factor Binding Protein to Modify the Coagulation Cascade and Establish Host Infections
McAdow M, Missiakas DM, Schneewind O. Staphylococcus aureus Secretes Coagulase and von Willebrand Factor Binding Protein to Modify the Coagulation Cascade and Establish Host Infections. Journal Of Innate Immunity 2012, 4: 141-148. PMID: 22222316, PMCID: PMC3388267, DOI: 10.1159/000333447.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsBacterial ProteinsBlood CoagulationCoagulaseHumansStaphylococcal InfectionsStaphylococcus aureusConceptsFormation of abscessesDrug-resistant S. aureusHost immune cellsHospital-acquired infectionsFactor binding proteinInnate defense mechanismsVon Willebrand factorThromboembolic lesionsClotting of plasmaPreclinical evidenceLethal sepsisImmune cellsStaphylococcal infectionsDisease pathogenesisCoagulation productsClinical isolatesCurrent epidemicKey innate defence mechanismCoagulation cascadeStaphylococcal productsInfectionWillebrand factorOpsonophagocytic clearanceHost infectionFibrin meshwork
2011
Preventing Staphylococcus aureus Sepsis through the Inhibition of Its Agglutination in Blood
McAdow M, Kim HK, DeDent AC, Hendrickx AP, Schneewind O, Missiakas DM. Preventing Staphylococcus aureus Sepsis through the Inhibition of Its Agglutination in Blood. PLOS Pathogens 2011, 7: e1002307. PMID: 22028651, PMCID: PMC3197598, DOI: 10.1371/journal.ppat.1002307.Peer-Reviewed Original ResearchMeSH KeywordsAgglutinationAnimalsAntibodies, NeutralizingAntithrombinsBacterial ProteinsCarrier ProteinsCoagulantsCoagulaseDisease Models, AnimalHeartHost-Pathogen InteractionsHumansImmunization, PassiveLongevityMiceMice, Inbred BALB CMyocardiumProtein BindingSepsisStaphylococcal InfectionsStaphylococcus aureusVon Willebrand FactorConceptsAureus sepsisLethal outcomeDabigatran etexilate treatmentS. aureus sepsisDirect thrombin inhibitorStaphylococcus aureus sepsisStaphylococcus aureus infectionVon Willebrand factorThromboembolic lesionsStaphylococcal sepsisAureus infectionFrequent causeMouse modelSepsisDisease pathogenesisHigh mortalityThrombin inhibitorsBacterial factorsSpecific interventionsHeart tissueWillebrand factorFibrin cableVirulence genesAgglutinationDisease
2010
Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity
Cheng AG, McAdow M, Kim HK, Bae T, Missiakas DM, Schneewind O. Contribution of Coagulases towards Staphylococcus aureus Disease and Protective Immunity. PLOS Pathogens 2010, 6: e1001036. PMID: 20700445, PMCID: PMC2916881, DOI: 10.1371/journal.ppat.1001036.Peer-Reviewed Original ResearchConceptsSpecific antibodiesFormation of abscessesHost immune cellsStaphylococcus aureus diseaseVon Willebrand factorProtective immunityAbscess formationStaphylococcal vaccineImmune cellsLethal bacteremiaNon-proteolytic activationAbscessCleavage of fibrinogenProtective antigenWillebrand factorS. aureusStaphylococcus aureusPseudocapsuleHistochemical stainingAntibodiesProthrombinHost tissuesCoagulaseVWbpAureus
2007
Distribution of Protein A on the Surface of Staphylococcus aureus
DeDent AC, McAdow M, Schneewind O. Distribution of Protein A on the Surface of Staphylococcus aureus. Journal Of Bacteriology 2007, 189: 4473-4484. PMID: 17416657, PMCID: PMC1913371, DOI: 10.1128/jb.00227-07.Peer-Reviewed Original Research