2023
Gender Differences in Long-Term Outcomes of Young Patients Who Underwent Percutaneous Coronary Intervention: Long-Term Outcome Analysis from a Multicenter Registry in Japan
Kuno T, Miyamoto Y, Sawano M, Kodaira M, Numasawa Y, Ueda I, Suzuki M, Noma S, Fukuda K, Kohsaka S. Gender Differences in Long-Term Outcomes of Young Patients Who Underwent Percutaneous Coronary Intervention: Long-Term Outcome Analysis from a Multicenter Registry in Japan. The American Journal Of Cardiology 2023, 206: 151-160. PMID: 37703680, DOI: 10.1016/j.amjcard.2023.08.106.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPrimary end pointLong-term outcomesYounger patientsCause deathCoronary interventionOlder patientsMale patientsAcute coronary syndrome casesPrimary end point ratesLong-term outcome analysisST-elevation myocardial infarctionEnd pointUnderwent Percutaneous Coronary InterventionWorse long-term outcomesYoung womenCoronary artery bypassAcute coronary syndromeConsecutive young patientsYoung female patientProportion of smokingNoncardiac deathArtery bypassCoronary syndromeMulticenter registry
2021
One-Year Outcome After Percutaneous Coronary Intervention for Acute Coronary Syndrome ― An Analysis of 20,042 Patients From a Japanese Nationwide Registry ―
Sawano M, Kohsaka S, Ishii H, Numasawa Y, Yamaji K, Inohara T, Amano T, Ikari Y, Nakamura M. One-Year Outcome After Percutaneous Coronary Intervention for Acute Coronary Syndrome ― An Analysis of 20,042 Patients From a Japanese Nationwide Registry ―. Circulation Journal 2021, 85: 1756-1767. PMID: 34162778, DOI: 10.1253/circj.cj-21-0098.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionST-elevation myocardial infarctionHeart failureHospital survivorsCoronary interventionIschemic strokeUnstable anginaMyocardial infarctionHigh riskAcute myocardial infarction populationNon-fatal ischemic strokeLate adverse cardiac eventsJapanese nationwide cohortJapanese nationwide registryNon-cardiac deathAcute heart failureAdverse cardiac eventsAcute coronary syndromeHeart failure eventsOne-year outcomesElevation myocardial infarctionSudden cardiac deathMyocardial infarction populationQuality of careACS patientsFemale sex as an independent predictor of high bleeding risk among East Asian percutaneous coronary intervention patients: A sex difference analysis
Kodaira M, Sawano M, Tanaka M, Kuno T, Numasawa Y, Ueda I, Fukuda K, Kohsaka S. Female sex as an independent predictor of high bleeding risk among East Asian percutaneous coronary intervention patients: A sex difference analysis. Journal Of Cardiology 2021, 78: 431-438. PMID: 34172350, DOI: 10.1016/j.jjcc.2021.05.016.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overFemaleHemorrhageHumansMaleMiddle AgedPercutaneous Coronary InterventionSex CharacteristicsTreatment OutcomeConceptsPercutaneous coronary interventionAcute coronary syndromeFine-Gray modelPrimary outcomeFemale sexPercutaneous coronary intervention patientsLower body mass indexEtiology of readmissionMulticenter PCI registryPrevious heart failureUnadjusted readmission ratesAdjusted hazard ratioHigh bleeding riskBody mass indexLong-term outcomesCox regression modelACS survivorsCumulative incidence functionMajor bleedingMore comorbiditiesBleeding riskCoronary syndromeIntervention patientsPCI registryCoronary interventionContemporary Management of Stable Coronary Artery Disease ― Implications of the ISCHEMIA Trial ―
Kohsaka S, Fukushima K, Watanabe I, Manabe S, Niimi N, Gatate Y, Sawano M, Nakano S. Contemporary Management of Stable Coronary Artery Disease ― Implications of the ISCHEMIA Trial ―. Circulation Journal 2021, 85: 1919-1927. PMID: 34148929, DOI: 10.1253/circj.cj-21-0345.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeClinical Trials as TopicCoronary AngiographyCoronary Artery DiseaseHumansIschemiaConceptsCoronary artery diseaseAcute coronary syndromeStable coronary artery diseaseRecent large-scale clinical trialsLarge-scale clinical trialsCornerstone of managementInvasive coronary angiographyDifferent clinical entitiesUrgent revascularizationCoronary syndromeArtery diseaseCoronary angiographyMedical therapyISCHEMIA trialClinical entityClinical trialsDiagnostic pathwayLeading causePretest probabilityContemporary managementOptimal timingRevascularizationTrialsDisease implicationsMorbidity
2020
Ischemic and Bleeding Events Among Patients With Acute Coronary Syndrome Associated With Low-Dose Prasugrel vs Standard-Dose Clopidogrel Treatment
Shoji S, Sawano M, Sandhu A, Heidenreich P, Shiraishi Y, Ikemura N, Ueno K, Suzuki M, Numasawa Y, Fukuda K, Kohsaka S. Ischemic and Bleeding Events Among Patients With Acute Coronary Syndrome Associated With Low-Dose Prasugrel vs Standard-Dose Clopidogrel Treatment. JAMA Network Open 2020, 3: e202004. PMID: 32239221, PMCID: PMC7118520, DOI: 10.1001/jamanetworkopen.2020.2004.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overAspirinBrain IschemiaCase-Control StudiesClopidogrelDeathDrug Therapy, CombinationFemaleHemorrhageHumansJapanMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPrasugrel HydrochlorideRegistriesRenal Insufficiency, ChronicRetrospective StudiesRisk AssessmentStrokeConceptsLow-dose prasugrelPercutaneous coronary interventionPrimary ischemic eventsAcute coronary syndromeBleeding eventsIschemic eventsCoronary syndromeST-segment elevation myocardial infarctionAcute Coronary Syndrome AssociatedPropensity score-matched analysisHigh-bleeding riskStandard-dose clopidogrelChronic kidney diseaseElevation myocardial infarctionPresent cohort studyShort-term outcomesEast Asian patientsReal-world outcomesPrasugrel treatmentClopidogrel administrationP2Y12 inhibitorsBaseline characteristicsClopidogrel treatmentCohort studyCoronary intervention
2019
In-hospital outcome in patients presenting with acute coronary syndrome with left main coronary artery disease: A report from Japanese prospective multicenter percutaneous coronary intervention registry
Tani H, Sawano M, Numasawa Y, Kobayashi Y, Suzuki M, Noma S, Shiraishi Y, Ueda I, Fukuda K, Kohsaka S. In-hospital outcome in patients presenting with acute coronary syndrome with left main coronary artery disease: A report from Japanese prospective multicenter percutaneous coronary intervention registry. Journal Of Cardiology 2019, 75: 635-640. PMID: 31899113, DOI: 10.1016/j.jjcc.2019.11.006.Peer-Reviewed Original ResearchConceptsAcute coronary syndromePercutaneous coronary interventionCardiogenic shockMortality rateACS patientsHospital mortalityCoronary syndromeHospital outcomesHigh riskLeft main coronary artery diseaseMain coronary artery diseasePresence of CSST-elevation myocardial infarctionPercutaneous coronary intervention registryContemporary risk modelsCoronary lesion characteristicsLeft main diseaseCoronary artery bypassHospital mortality rateDe novo patientsElevation myocardial infarctionCoronary artery diseaseCoronary Intervention RegistryShort-term outcomesKey clinical characteristicsOutcomes of acute coronary syndrome patients with concurrent extra-cardiac vascular disease in the era of transradial coronary intervention: A retrospective multicenter cohort study
Kodaira M, Sawano M, Kuno T, Numasawa Y, Noma S, Suzuki M, Imaeda S, Ueda I, Fukuda K, Kohsaka S. Outcomes of acute coronary syndrome patients with concurrent extra-cardiac vascular disease in the era of transradial coronary intervention: A retrospective multicenter cohort study. PLOS ONE 2019, 14: e0223215. PMID: 31618228, PMCID: PMC6795465, DOI: 10.1371/journal.pone.0223215.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAged, 80 and overCerebrovascular DisordersFemaleHospital MortalityHumansIncidenceMaleMiddle AgedPercutaneous Coronary InterventionPeripheral Vascular DiseasesPostoperative HemorrhageRadial ArteryRegistriesRetrospective StudiesRisk FactorsSeverity of Illness IndexTreatment OutcomeConceptsTransradial coronary interventionAcute coronary syndromePeripheral arterial diseaseCerebrovascular diseaseCoronary interventionVascular diseaseRetrospective multicenter cohort studyAcute coronary syndrome patientsPercutaneous coronary intervention registryMulticenter cohort studyCoronary syndrome patientsCoronary Intervention RegistryIncidence of deathCoronary syndromeCohort studyIntervention RegistryArterial diseaseAdverse outcomesRisk factorsPatient outcomesAccess siteSyndrome patientsHigh riskComplicationsPatients
2017
Relation of Baseline Hemoglobin Level to In-Hospital Outcomes in Patients Who Undergo Percutaneous Coronary Intervention (from a Japanese Multicenter Registry)
Numasawa Y, Ueda I, Sawano M, Kuno T, Kodaira M, Noma S, Suzuki M, Miyata H, Fukuda K, Kohsaka S. Relation of Baseline Hemoglobin Level to In-Hospital Outcomes in Patients Who Undergo Percutaneous Coronary Intervention (from a Japanese Multicenter Registry). The American Journal Of Cardiology 2017, 121: 695-702. PMID: 29361289, DOI: 10.1016/j.amjcard.2017.12.007.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionBaseline hemoglobinLower hemoglobin levelsHemoglobin levelsHospital mortalityCoronary interventionProcedural complicationsCases of PCIStable coronary artery diseaseHospital adverse outcomesJapanese multicenter registryLower baseline hemoglobinBaseline hemoglobin levelIn-Hospital OutcomesAcute coronary syndromeCoronary artery diseaseHigher hemoglobin levelsHospital complicationsPreprocedural hemoglobinCoronary syndromeHospital outcomesMulticenter registryRenal failureArtery diseaseDiabetes mellitusPrognostic Impact of Subsequent Acute Coronary Syndrome and Unplanned Revascularization on Long‐Term Mortality After an Index Percutaneous Coronary Intervention: A Report From a Japanese Multicenter Registry
Inohara T, Kohsaka S, Miyata H, Sawano M, Ueda I, Maekawa Y, Fukuda K, Jones PG, Cohen DJ, Zhao Z, Spertus JA, Smolderen KG. Prognostic Impact of Subsequent Acute Coronary Syndrome and Unplanned Revascularization on Long‐Term Mortality After an Index Percutaneous Coronary Intervention: A Report From a Japanese Multicenter Registry. Journal Of The American Heart Association 2017, 6: e006529. PMID: 29079567, PMCID: PMC5721753, DOI: 10.1161/jaha.117.006529.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedAngina, UnstableChi-Square DistributionFemaleHospitals, TeachingHumansIncidenceJapanLogistic ModelsMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPropensity ScoreProportional Hazards ModelsRegistriesRetreatmentRisk FactorsTime FactorsTreatment OutcomeConceptsSubsequent acute coronary syndromeAcute coronary syndromePercutaneous coronary interventionPropensity-matched cohortUnplanned coronary revascularizationIndex percutaneous coronary interventionComposite end pointUnplanned revascularizationCoronary revascularizationCoronary syndromeCoronary interventionUnstable anginaClinical trialsEnd pointJapanese multicenter registryLong-term mortalityAcute myocardial infarctionRisk of mortalityProportional hazards modelLong-term survivalJapanese teaching hospitalsCause mortalityMulticenter registryPCI patientsSubsequent survivalCharacteristics and in-hospital outcomes in young patients presenting with acute coronary syndrome treated by percutaneous coronary intervention
Hirota Y, Sawano M, Numasawa Y, Ueda I, Noma S, Suzuki M, Hayashida K, Yuasa S, Maekawa Y, Kohsaka S, Fukuda K. Characteristics and in-hospital outcomes in young patients presenting with acute coronary syndrome treated by percutaneous coronary intervention. Cardiovascular Intervention And Therapeutics 2017, 33: 154-162. PMID: 28585049, DOI: 10.1007/s12928-017-0471-z.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedFemaleHospital MortalityHumansMaleMiddle AgedPercutaneous Coronary InterventionPrognosisRegistriesRisk FactorsShock, CardiogenicConceptsAcute coronary syndromeCoronary artery diseaseMulti-vessel diseaseClassical risk factorsCardiogenic shockYounger patientsACS patientsHospital mortalityCoronary syndromeCulprit lesionRisk factorsFamily historyPremature coronary artery diseaseHigher body mass indexPercutaneous coronary intervention registryConsecutive ACS patientsYoung ACS patientsPrevalence of dyslipidemiaChronic kidney diseasePercutaneous coronary interventionCoronary Intervention RegistryBody mass indexCS presentationLonger life expectancyHospital outcomesOutcomes After Percutaneous Coronary Intervention of Acute Coronary Syndrome Complicated With Cardiopulmonary Arrest (from a Japanese Multicenter Registry)
Numasawa Y, Sawano M, Miyata H, Ueda I, Noma S, Suzuki M, Kuno T, Kodaira M, Maekawa Y, Fukuda K, Kohsaka S. Outcomes After Percutaneous Coronary Intervention of Acute Coronary Syndrome Complicated With Cardiopulmonary Arrest (from a Japanese Multicenter Registry). The American Journal Of Cardiology 2017, 119: 1173-1178. PMID: 28236456, DOI: 10.1016/j.amjcard.2017.01.007.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAge FactorsAgedBody Mass IndexFemaleHeart ArrestHospital MortalityHumansHypothermia, InducedJapanMaleMiddle AgedMultivariate AnalysisNo-Reflow PhenomenonPercutaneous Coronary InterventionProspective StudiesRegistriesShock, CardiogenicST Elevation Myocardial InfarctionConceptsAcute coronary syndromePercutaneous coronary interventionST-elevation myocardial infarctionCardiopulmonary arrestCardiogenic shockCoronary interventionInhospital mortalityMortality rateAcute Coronary Syndrome ComplicatedPresence of CSHours of admissionHigh mortality rateInhospital outcomesCoronary syndromeUnstable anginaIndependent predictorsShock statusMyocardial infarctionPatientsMultivariate analysisOlder ageInterventionOutcomesMortalityAge
2016
Degree of dyspnoea in patients with non‐ST‐elevation acute coronary syndrome: A report from Japanese multicenter registry
Shiraishi Y, Kohsaka S, Ueda I, Inohara T, Sawano M, Numasawa Y, Hayashida K, Maekawa Y, Momiyama Y, Fukuda K. Degree of dyspnoea in patients with non‐ST‐elevation acute coronary syndrome: A report from Japanese multicenter registry. International Journal Of Clinical Practice 2016, 70: 978-987. PMID: 28032431, DOI: 10.1111/ijcp.12905.Peer-Reviewed Original ResearchConceptsAcute heart failureAcute coronary syndromeElevation acute coronary syndromeDegree of dyspnoeaDyspnoea severityRenal eventsMajor cardiovascularHospital mortalityCoronary syndromeNon-ST elevation acute coronary syndromeJapanese multicenter registryMulticenter PCI registryNSTE-ACS patientsRenal event rateMild activityDyspnoeic symptomsNSTE-ACSHospital deathHospital outcomesMulticenter registryPCI registryMultivariate adjustmentConsecutive patientsHeart failureDyspnoea