Min Wang, PhD
Senior Research Scientist in NeuroscienceDownloadHi-Res Photo
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Senior Research Scientist in Neuroscience
Appointments
Neuroscience
Senior Research ScientistPrimary
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Education & Training
- PhD
- Shanghai Institute of Physiology, Chinese Academy of Sciences (2001)
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Research at a Glance
Yale Co-Authors
Frequent collaborators of Min Wang's published research.
Publications Timeline
A big-picture view of Min Wang's research output by year.
Amy Arnsten, PhD
Dibyadeep Datta
Alvaro Duque, PhD
Christopher van Dyck, MD
Juan Arellano, PhD
Angus Nairn, PhD
14Publications
2,311Citations
Publications
2024
Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders
Datta D, Yang S, Joyce M, Woo E, McCarroll S, Gonzalez-Burgos G, Perone I, Uchendu S, Ling E, Goldman M, Berretta S, Murray J, Morozov Y, Arellano J, Duque A, Rakic P, O’Dell R, van Dyck C, Lewis D, Wang M, Krienen F, Arnsten A. Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders. JAMA Psychiatry 2024, 81: 870-881. PMID: 38776078, PMCID: PMC11112502, DOI: 10.1001/jamapsychiatry.2024.1112.Peer-Reviewed Original ResearchCitationsAltmetricConceptsDorsolateral prefrontal cortexPrefrontal cortexLayer III pyramidal cellsWorking memoryCognitive disordersNeuronal firingPrimate dorsolateral prefrontal cortexPyramidal cellsSpatial working memoryWorking memory performanceRisk of mental disordersCalcium-related proteinsReduced neuronal firingL-type calcium channel Cav1.2GluN2B-NMDA receptorsL-type calcium channel activityPrefrontal neuronsL-type calcium channel blockerMemory performanceL-type calcium channelsMental disordersRisk of cognitive disordersCognitive behaviorProtein expressionAssociated with increased riskβ1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction
Joyce M, Yang S, Morin K, Duque A, Arellano J, Datta D, Wang M, Arnsten A. β1-adrenoceptor expression on GABAergic interneurons in primate dorsolateral prefrontal cortex: potential role in stress-induced cognitive dysfunction. Neurobiology Of Stress 2024, 30: 100628. PMID: 38550854, PMCID: PMC10973161, DOI: 10.1016/j.ynstr.2024.100628.Peer-Reviewed Original ResearchCitationsAltmetricConceptsDorsolateral prefrontal cortexPrefrontal cortexStress-induced cognitive dysfunctionTreat stress-related disordersPrimate dorsolateral prefrontal cortexImpaired working memoryWorking memory deficitsWorking memory taskCalcium-binding proteins calbindinStress-related disordersClasses of inhibitory neuronsLevels of norepinephrineFast-spikingMemory taskDopamine releaseWorking memoryMemory deficitsInhibitory neuronsCognitive dysfunctionPV interneuronsGABAergic interneuronsDlPFCBehavior analysisCortexPyramidal cellsDynamic Network Connectivity: from monkeys to humans
Arnsten A, Wang M, D’Esposito M. Dynamic Network Connectivity: from monkeys to humans. Frontiers In Human Neuroscience 2024, 18: 1353043. PMID: 38384333, PMCID: PMC10879414, DOI: 10.3389/fnhum.2024.1353043.Peer-Reviewed Original ResearchCitationsAltmetricConceptsDynamic network connectivityFunctional MRIFunctional connectivityHuman brain imaging researchDorsolateral prefrontal cortexNMDA receptor neurotransmissionBrain imaging researchHuman fMRI studiesPrefrontal cortexReceptor neurotransmissionWorking memoryFMRI studyBrain regionsPersistent neuronal firingNeuromodulator acetylcholineCognitive disordersCortical regionsDlPFCPost-synaptic densityArousal stateStrength of synaptic connectionsNeuronal firingCognitive statesImaging researchDendritic spines
2023
Scientific Rationale for the Treatment of Cognitive Deficits from Long COVID
Zadeh A, Arnsten A, Wang M. Scientific Rationale for the Treatment of Cognitive Deficits from Long COVID. Neurology International 2023, 15: 725-742. PMID: 37368329, PMCID: PMC10303664, DOI: 10.3390/neurolint15020045.Peer-Reviewed Original ResearchCitationsAltmetricConceptsLong COVIDGlutamate carboxypeptidase IIKynurenic acidNicotinic alpha 7 receptorCognitive deficitsProduction of KYNACOVID-19 infectionDorsolateral prefrontal cortexAgonist guanfacineNeuronal firingCognitive symptomsAcetyl cysteineCognitive functionPrefrontal cortexScientific rationaleCarboxypeptidase IIPFC functionCOVIDDeficitsReceptorsTreatmentExecutive functioningNMDAGuanfacineNeurotransmission
2020
Biochemical characterization of age‐related calcium‐cAMP‐PKA signaling dysregulation and its effect on tau pathology in rhesus monkey cortex
Leslie S, Datta D, Wang M, van Dyck C, Arnsten A, Nairn A. Biochemical characterization of age‐related calcium‐cAMP‐PKA signaling dysregulation and its effect on tau pathology in rhesus monkey cortex. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.042017.Peer-Reviewed Original ResearchConceptsTau pathologyAge-related dysregulationAlzheimer's diseaseIntracellular calciumTau phosphorylationRhesus monkeysRat primary cortical culturesHuman post-mortem samplesVulnerable brain regionsSporadic Alzheimer's diseaseAmyloid-beta plaquesPrimary cortical culturesMain pathological hallmarksRhesus monkey cortexTau neurofibrillary tanglesYears of ageEarly-onset formAge-related vulnerabilityDorsolateral prefrontal cortexAge-related changesMonkey DLPFCPost-mortem samplesAD pathologyAmyloid pathologyUnknown etiology
2017
mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions
Jin L, Wang M, Yang S, Yang Y, Galvin V, Lightbourne T, Ottenheimer D, Zhong Q, Stein J, Raja A, Paspalas C, Arnsten A. mGluR2/3 mechanisms in primate dorsolateral prefrontal cortex: evidence for both presynaptic and postsynaptic actions. Molecular Psychiatry 2017, 22: 1511-1511. DOI: 10.1038/mp.2017.206.Peer-Reviewed Original ResearchAltmetric
2013
Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex
Yang Y, Paspalas CD, Jin LE, Picciotto MR, Arnsten AF, Wang M. Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 12078-12083. PMID: 23818597, PMCID: PMC3718126, DOI: 10.1073/pnas.1307849110.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAcetylcholineAconitineAlpha7 Nicotinic Acetylcholine ReceptorAnalysis of VarianceAnimalsBridged Bicyclo Compounds, HeterocyclicCholinergic AgonistsCholinergic AntagonistsCognitionFemaleIontophoresisMacaca mulattaMaleMecamylamineMicroscopy, ImmunoelectronN-MethylaspartatePhenolsPiperidinesPrefrontal CortexQuinuclidinesReceptors, NicotinicSpatial BehaviorSynapsesVisual PerceptionConceptsDorsolateral prefrontal cortexΑ7 nAChRsPrefrontal cortexΑ7 nicotinic acetylcholine receptorGlutamatergic NMDA receptorsCognitive circuitsNicotinic α7 receptorsPrimary visual cortexNMDA receptor actionGenetic insultsNicotinic acetylcholine receptorsDlPFC circuitsPrimate dlPFCACh depletionNMDA actionNMDA receptorsPyramidal cellsΑ7 receptorsNeuronal firingNAChR blockadeAcetylcholine receptorsVisual cortexPersistent firingCognitive functionLow-dose stimulationNMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex
Wang M, Yang Y, Wang CJ, Gamo NJ, Jin LE, Mazer JA, Morrison JH, Wang XJ, Arnsten AF. NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex. Neuron 2013, 77: 736-749. PMID: 23439125, PMCID: PMC3584418, DOI: 10.1016/j.neuron.2012.12.032.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPersistent firingDorsolateral prefrontal cortexAMPA receptorsPrefrontal cortexPrimate dorsolateral prefrontal cortexSystemic ketamine administrationPersistent neuronal firingAMPAR blockadePrimate dlPFCKetamine actionKetamine administrationNMDAR blockadeNMDA receptorsSystemic ketamineNetwork firingNeuronal firingAlzheimer's diseaseReceptor influencesImpair cognitionResponse cellsRecurrent excitationSensory stimulation
2012
Constellation of HCN Channels and cAMP Regulating Proteins in Dendritic Spines of the Primate Prefrontal Cortex: Potential Substrate for Working Memory Deficits in Schizophrenia
Paspalas CD, Wang M, Arnsten AF. Constellation of HCN Channels and cAMP Regulating Proteins in Dendritic Spines of the Primate Prefrontal Cortex: Potential Substrate for Working Memory Deficits in Schizophrenia. Cerebral Cortex 2012, 23: 1643-1654. PMID: 22693343, PMCID: PMC3673177, DOI: 10.1093/cercor/bhs152.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsAnimalsCyclic AMPCyclic Nucleotide Phosphodiesterases, Type 4Dendritic SpinesHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsImmunohistochemistryMacaca mulattaMemory DisordersMemory, Short-TermMicroscopy, ImmunoelectronPatch-Clamp TechniquesPrefrontal CortexReceptors, Dopamine D1Schizophrenia
2010
Methylphenidate and Atomoxetine Enhance Prefrontal Function Through α2-Adrenergic and Dopamine D1 Receptors
Gamo NJ, Wang M, Arnsten AF. Methylphenidate and Atomoxetine Enhance Prefrontal Function Through α2-Adrenergic and Dopamine D1 Receptors. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 49: 1011-1023. PMID: 20855046, PMCID: PMC2999884, DOI: 10.1016/j.jaac.2010.06.015.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAdrenergic Uptake InhibitorsAnimalsAppetitive BehaviorAtomoxetine HydrochlorideAttention Deficit Disorder with HyperactivityBrain MappingCentral Nervous System StimulantsChildDisease Models, AnimalDose-Response Relationship, DrugFemaleHumansMacaca mulattaMaleMemory, Short-TermMethylphenidateNerve NetOrientationPrefrontal CortexPropylaminesPyramidal CellsReceptors, Adrenergic, alpha-2Receptors, Dopamine D1SaccadesConceptsAttention-deficit/hyperactivity disorder treatmentOptimal dosesPFC cognitive functionDopamine receptor antagonistDopamine D1 receptorsAttention-deficit/hyperactivity disorderAdrenoceptor antagonistPrefrontal cortex functionΑ2-adrenergicCellular levelReceptor antagonistD1 receptorsDopamine receptorsTherapeutic effectReceptor mechanismsSCH23390Moderate dosesAtomoxetineIndirect stimulationDisorder treatmentHigh dosesCortex functionPersistent firingCognitive functionReceptor action
Academic Achievements & Community Involvement
honor Alzheimer’s Association New Investigator Research Award 2011
Other AwardDetails07/01/2011honor NARSAD Young Investigator Award 2004
Other AwardDetails07/01/2004
News
News
- June 24, 2014Source: New Haven Register
Yale stem cell researchers receive $5.6 million in state grants
- March 17, 2014
How age opens the gates for Alzheimer’s
- February 20, 2013
Human cognition depends upon slow-firing neurons, Yale researchers find
- October 01, 2011
New hope for old brains seen in study of memory
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