Comparison of the Test-negative Design and Cohort Design With Explicit Target Trial Emulation for Evaluating COVID-19 Vaccine Effectiveness
Li G, Gerlovin H, Muñiz M, Wise J, Madenci A, Robins J, Aslan M, Cho K, Gaziano J, Lipsitch M, Casas J, Hernán M, Dickerman B. Comparison of the Test-negative Design and Cohort Design With Explicit Target Trial Emulation for Evaluating COVID-19 Vaccine Effectiveness. Epidemiology 2023, 35: 137-149. PMID: 38109485, PMCID: PMC11022682, DOI: 10.1097/ede.0000000000001709.Peer-Reviewed Original ResearchTest-negative designTarget trial emulationVaccine effectivenessCohort designTrial emulationResidual confoundingCOVID-19 vaccine effectivenessHealth care-seeking behaviorBNT162b2 vaccine effectivenessCare-seeking behaviorCOVID-19 outcomesVA healthcare systemCOVID-19 vaccineBNT162b2 vaccineAbsolute riskObservational studyNationwide dataVeterans AffairsTarget trialsEffect estimatesHealthcare systemVaccineCohortNegative controlTrialsMetformin prescription for U.S. veterans with prediabetes, 2010–2019
Gulanski B, Goulet J, Radhakrishnan K, Ko J, Li Y, Rajeevan N, Lee K, Heberer K, Lynch J, Streja E, Mutalik P, Cheung K, Concato J, Shih M, Lee J, Aslan M. Metformin prescription for U.S. veterans with prediabetes, 2010–2019. Journal Of Investigative Medicine 2023, 72: 139-150. PMID: 37668313, DOI: 10.1177/10815589231201141.Peer-Reviewed Original ResearchConceptsBody mass indexVeterans Health AdministrationIncident prediabetesHigh riskHealth AdministrationRetrospective observational cohort studyType 2 diabetes mellitusUse of metforminObservational cohort studyProportion of veteransMetformin prescribingGestational diabetesCohort studyMetformin prescriptionDiabetes mellitusDiabetes preventionMass indexCardiovascular diseaseMultivariable modelPrediabetesSubset of individualsMetforminU.S. veteransHealthcare systemVeterans561. Lifetime Consequences and Correlates of Anticholinergic Medication Burden in the VA Healthcare System
Bigdeli T, Joshi Y, Li Y, Rajeevan N, Sayward F, Przygodszki R, Huang G, Pyarajan S, Muralidhar S, Gaziano J, Braff D, Light G, Aslan M, Roussos P, Harvey P. 561. Lifetime Consequences and Correlates of Anticholinergic Medication Burden in the VA Healthcare System. Biological Psychiatry 2023, 93: s321. DOI: 10.1016/j.biopsych.2023.02.801.Peer-Reviewed Original Research