Comparison of the Test-negative Design and Cohort Design With Explicit Target Trial Emulation for Evaluating COVID-19 Vaccine Effectiveness
Li G, Gerlovin H, Muñiz M, Wise J, Madenci A, Robins J, Aslan M, Cho K, Gaziano J, Lipsitch M, Casas J, Hernán M, Dickerman B. Comparison of the Test-negative Design and Cohort Design With Explicit Target Trial Emulation for Evaluating COVID-19 Vaccine Effectiveness. Epidemiology 2023, 35: 137-149. PMID: 38109485, PMCID: PMC11022682, DOI: 10.1097/ede.0000000000001709.Peer-Reviewed Original ResearchTest-negative designTarget trial emulationVaccine effectivenessCohort designTrial emulationResidual confoundingCOVID-19 vaccine effectivenessHealth care-seeking behaviorBNT162b2 vaccine effectivenessCare-seeking behaviorCOVID-19 outcomesVA healthcare systemCOVID-19 vaccineBNT162b2 vaccineAbsolute riskObservational studyNationwide dataVeterans AffairsTarget trialsEffect estimatesHealthcare systemVaccineCohortNegative controlTrials